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Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration

Minthon, Lennart LU ; Edvinsson, Lars LU ; Ekman, R and Gustafson, Lars LU (1990) In Journal of neural transmission. Supplementum 30. p.57-67
Abstract
The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted... (More)
The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias. (Less)
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type
Contribution to journal
publication status
published
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in
Journal of neural transmission. Supplementum
volume
30
pages
57 - 67
publisher
Springer
external identifiers
  • scopus:0025035230
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Faculty of Medicine (000022000), Clinical Memory Research Unit (013242610), Medicine (Lund) (013230025), Department of Psychogeriatrics (013304000)
id
c31f3951-0715-4fc3-bc75-9c1a6ee4766b (old id 1296189)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed?term=1975266
date added to LUP
2016-04-04 13:53:49
date last changed
2024-01-13 10:05:34
@article{c31f3951-0715-4fc3-bc75-9c1a6ee4766b,
  abstract     = {{The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias.}},
  author       = {{Minthon, Lennart and Edvinsson, Lars and Ekman, R and Gustafson, Lars}},
  language     = {{eng}},
  pages        = {{57--67}},
  publisher    = {{Springer}},
  series       = {{Journal of neural transmission. Supplementum}},
  title        = {{Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration}},
  url          = {{http://www.ncbi.nlm.nih.gov/pubmed?term=1975266}},
  volume       = {{30}},
  year         = {{1990}},
}