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Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration

Minthon, Lennart LU ; Edvinsson, Lars LU ; Ekman, R and Gustafson, Lars LU (1990) In Journal of neural transmission. Supplementum 30. p.57-67
Abstract
The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted... (More)
The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias. (Less)
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Contribution to journal
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in
Journal of neural transmission. Supplementum
volume
30
pages
57 - 67
language
English
LU publication?
yes
id
c31f3951-0715-4fc3-bc75-9c1a6ee4766b (old id 1296189)
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http://www.ncbi.nlm.nih.gov/pubmed?term=1975266
date added to LUP
2012-12-12 15:02:42
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2016-04-16 11:49:16
@misc{c31f3951-0715-4fc3-bc75-9c1a6ee4766b,
  abstract     = {The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias.},
  author       = {Minthon, Lennart and Edvinsson, Lars and Ekman, R and Gustafson, Lars},
  language     = {eng},
  pages        = {57--67},
  series       = {Journal of neural transmission. Supplementum},
  title        = {Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration},
  volume       = {30},
  year         = {1990},
}