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Redistribution of blood flow in the cerebral cortex of normal subjects during head-up postural change

Warkentin, Siegbert LU ; Passant, Ulla LU ; Minthon, Lennart LU ; Karlson, S; Edvinsson, Lars LU ; Fäldt, Roger LU ; Gustafson, Lars LU and Risberg, Jarl LU (1992) In Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2(2). p.119-124
Abstract
Regional cerebral blood flow was measured in 21 normotensive subjects during supine rest and during head-up tilt to 70 degrees. The results showed significant and consistent regional cerebral blood flow changes in the frontal areas with lower relative flow distribution values (percentage of mean flow) during head-up tilt than during supine rest. The lower frontal flow distribution values during tilt were not related to habituation, to repeated measurements, or to the estimated level of arterial CO2 which was derived from expired end-tidal CO2 levels. None of the subjects had orthostatic hypotension and there was no significant difference in mean hemispheric blood flow between lying down and standing up. There was no significant gender... (More)
Regional cerebral blood flow was measured in 21 normotensive subjects during supine rest and during head-up tilt to 70 degrees. The results showed significant and consistent regional cerebral blood flow changes in the frontal areas with lower relative flow distribution values (percentage of mean flow) during head-up tilt than during supine rest. The lower frontal flow distribution values during tilt were not related to habituation, to repeated measurements, or to the estimated level of arterial CO2 which was derived from expired end-tidal CO2 levels. None of the subjects had orthostatic hypotension and there was no significant difference in mean hemispheric blood flow between lying down and standing up. There was no significant gender difference in regional cerebral blood flow, although female subjects tended to have higher mean hemispheric flow than males in both postures. It remains to be established whether the flow decreases in the frontal cortex are caused by cerebral functional factors or by haemodynamic mechanisms. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
volume
2
issue
2
pages
119 - 124
external identifiers
  • Scopus:0026842403
language
English
LU publication?
yes
id
d1f69d0e-63ed-4ca1-aafc-49eec78f4a21 (old id 1296228)
date added to LUP
2012-12-12 14:11:50
date last changed
2016-10-13 04:57:42
@misc{d1f69d0e-63ed-4ca1-aafc-49eec78f4a21,
  abstract     = {Regional cerebral blood flow was measured in 21 normotensive subjects during supine rest and during head-up tilt to 70 degrees. The results showed significant and consistent regional cerebral blood flow changes in the frontal areas with lower relative flow distribution values (percentage of mean flow) during head-up tilt than during supine rest. The lower frontal flow distribution values during tilt were not related to habituation, to repeated measurements, or to the estimated level of arterial CO2 which was derived from expired end-tidal CO2 levels. None of the subjects had orthostatic hypotension and there was no significant difference in mean hemispheric blood flow between lying down and standing up. There was no significant gender difference in regional cerebral blood flow, although female subjects tended to have higher mean hemispheric flow than males in both postures. It remains to be established whether the flow decreases in the frontal cortex are caused by cerebral functional factors or by haemodynamic mechanisms.},
  author       = {Warkentin, Siegbert and Passant, Ulla and Minthon, Lennart and Karlson, S and Edvinsson, Lars and Fäldt, Roger and Gustafson, Lars and Risberg, Jarl},
  language     = {eng},
  number       = {2},
  pages        = {119--124},
  series       = {Clinical autonomic research : official journal of the Clinical Autonomic Research Society},
  title        = {Redistribution of blood flow in the cerebral cortex of normal subjects during head-up postural change},
  volume       = {2},
  year         = {1992},
}