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Long-term effects of tacrine on regional cerebral blood flow changes in Alzheimer's disease

Minthon, Lennart LU ; Nilsson, Karin LU ; Edvinsson, Lars LU ; Wendt, P E and Gustafson, Lars LU (1995) In Dementia (Basel, Switzerland) 6(5). p.245-251
Abstract
Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer's disease (AD) before and after 14 months of tacrine treatment. The treated group was compared with an identical reference group of untreated AD patients. At baseline the two groups showed an identical rCBF and mean hemispheric blood flow. After 14 months the tacrine-treated patients showed a stable rCBF level and a significant increase in rCBF in the central-parietal regions, compared to the untreated reference group, who showed typical AD reductions in rCBF in these regions. Clinical outcome: 7 of 9 patients in the tacrine group were clinically unchanged or slightly improved during the study time. In the untreated group 8 of 11 patients had deteriorated in... (More)
Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer's disease (AD) before and after 14 months of tacrine treatment. The treated group was compared with an identical reference group of untreated AD patients. At baseline the two groups showed an identical rCBF and mean hemispheric blood flow. After 14 months the tacrine-treated patients showed a stable rCBF level and a significant increase in rCBF in the central-parietal regions, compared to the untreated reference group, who showed typical AD reductions in rCBF in these regions. Clinical outcome: 7 of 9 patients in the tacrine group were clinically unchanged or slightly improved during the study time. In the untreated group 8 of 11 patients had deteriorated in clinical assessments and none had improved. Long-term tacrine treatment in Alzheimer's disease may delay the progression of symptoms. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Dementia (Basel, Switzerland)
volume
6
issue
5
pages
245 - 251
language
English
LU publication?
yes
id
a42a0f99-94fd-4913-b3c1-936a0a2ea31b (old id 1296330)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed?term=Long-term%20effects%20of%20tacrine%20on%20regional%20cerebral%20blood%20flow%20changes%20in%20Alzheimer's%20disease
date added to LUP
2012-12-12 15:12:07
date last changed
2016-04-16 12:24:01
@misc{a42a0f99-94fd-4913-b3c1-936a0a2ea31b,
  abstract     = {Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer's disease (AD) before and after 14 months of tacrine treatment. The treated group was compared with an identical reference group of untreated AD patients. At baseline the two groups showed an identical rCBF and mean hemispheric blood flow. After 14 months the tacrine-treated patients showed a stable rCBF level and a significant increase in rCBF in the central-parietal regions, compared to the untreated reference group, who showed typical AD reductions in rCBF in these regions. Clinical outcome: 7 of 9 patients in the tacrine group were clinically unchanged or slightly improved during the study time. In the untreated group 8 of 11 patients had deteriorated in clinical assessments and none had improved. Long-term tacrine treatment in Alzheimer's disease may delay the progression of symptoms.},
  author       = {Minthon, Lennart and Nilsson, Karin and Edvinsson, Lars and Wendt, P E and Gustafson, Lars},
  language     = {eng},
  number       = {5},
  pages        = {245--251},
  series       = {Dementia (Basel, Switzerland)},
  title        = {Long-term effects of tacrine on regional cerebral blood flow changes in Alzheimer's disease},
  volume       = {6},
  year         = {1995},
}