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Många vägar leder till artros. Kunskapen om riskfaktorer och sjukdomsmekanismer ökar snabbt

Lohmander, Stefan LU (2002) In Läkartidningen 99(45). p.3-4480
Abstract

Osteoarthritis does not deserve the term "degenerative joint disease", the course of the disease is characterized by dynamic changes in both synthesis and degradation of cartilage and other joint tissues. At the end stage all tissues of the joint are involved, not only the cartilage. In the early phases of the disease, changes in cartilage metabolism can be detected through assay of biomarkers in joint fluid, blood or urine. These changes evolve into macroscopic changes of fibrillation and loss of cartilage. Concomitantly, changes occur in other joint tissues and bone. The more advanced stages of change, as loss of joint space and osteophytes, may be detected by radiological examination. Osteoarthritis is a complex disease where genetic... (More)

Osteoarthritis does not deserve the term "degenerative joint disease", the course of the disease is characterized by dynamic changes in both synthesis and degradation of cartilage and other joint tissues. At the end stage all tissues of the joint are involved, not only the cartilage. In the early phases of the disease, changes in cartilage metabolism can be detected through assay of biomarkers in joint fluid, blood or urine. These changes evolve into macroscopic changes of fibrillation and loss of cartilage. Concomitantly, changes occur in other joint tissues and bone. The more advanced stages of change, as loss of joint space and osteophytes, may be detected by radiological examination. Osteoarthritis is a complex disease where genetic variations in several loci appear to interact with environmental factors to initiate and drive disease progression towards several different phenotypes. These may be recognized in different joint patterns, predominant inflammation or lack of inflammation, predominant loss of joint space or osteophytosis, etc. Increased occupational joint load, joint injuries and obesity are well recognized risk factors for osteoarthritis.

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Please use this url to cite or link to this publication:
author
organization
alternative title
Many paths converge in arthritis. Awareness of risk factors and illness mechanisms increase steadily
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Age Factors, Aged, Cartilage, Articular, Female, Genetic Predisposition to Disease, Humans, Joints, Male, Middle Aged, Osteoarthritis, Risk Factors, Sex Factors
in
Läkartidningen
volume
99
issue
45
pages
4 pages
publisher
Sveriges Läkarförbund
external identifiers
  • Scopus:0037038243
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
12b10ffd-884e-4bf8-96be-263c643ad6c9
date added to LUP
2016-05-06 10:52:13
date last changed
2016-10-13 05:08:09
@misc{12b10ffd-884e-4bf8-96be-263c643ad6c9,
  abstract     = {<p>Osteoarthritis does not deserve the term "degenerative joint disease", the course of the disease is characterized by dynamic changes in both synthesis and degradation of cartilage and other joint tissues. At the end stage all tissues of the joint are involved, not only the cartilage. In the early phases of the disease, changes in cartilage metabolism can be detected through assay of biomarkers in joint fluid, blood or urine. These changes evolve into macroscopic changes of fibrillation and loss of cartilage. Concomitantly, changes occur in other joint tissues and bone. The more advanced stages of change, as loss of joint space and osteophytes, may be detected by radiological examination. Osteoarthritis is a complex disease where genetic variations in several loci appear to interact with environmental factors to initiate and drive disease progression towards several different phenotypes. These may be recognized in different joint patterns, predominant inflammation or lack of inflammation, predominant loss of joint space or osteophytosis, etc. Increased occupational joint load, joint injuries and obesity are well recognized risk factors for osteoarthritis.</p>},
  author       = {Lohmander, Stefan},
  issn         = {0023-7205},
  keyword      = {Adult,Age Factors,Aged,Cartilage, Articular,Female,Genetic Predisposition to Disease,Humans,Joints,Male,Middle Aged,Osteoarthritis,Risk Factors,Sex Factors},
  language     = {swe},
  month        = {11},
  number       = {45},
  pages        = {3--4480},
  publisher    = {ARRAY(0x9630de0)},
  series       = {Läkartidningen},
  title        = {Många vägar leder till artros. Kunskapen om riskfaktorer och sjukdomsmekanismer ökar snabbt},
  volume       = {99},
  year         = {2002},
}