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Cytokines and systemic biomarkers are related to the size of abdominal aortic aneurysms.

Flondell-Sité, Despina LU ; Lindblad, Bengt LU ; Kölbel, Tilo LU and Gottsäter, Anders LU (2009) In Cytokine 46. p.211-215
Abstract
Objective: The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth. Material and methods: Prospectively 360 AAA-patients and an age and sex-matched healthy control group (n=219) were analyzed. AAA-patients were divided in three groups according to AAA-diameter (small <45mm, n=122, medium 45-55mm, n=108, and large >55mm, n=130). Associated diseases, blood pressures and routine laboratory markers were analyzed. Additionally we evaluated endothelin (ET)-1, tumour... (More)
Objective: The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth. Material and methods: Prospectively 360 AAA-patients and an age and sex-matched healthy control group (n=219) were analyzed. AAA-patients were divided in three groups according to AAA-diameter (small <45mm, n=122, medium 45-55mm, n=108, and large >55mm, n=130). Associated diseases, blood pressures and routine laboratory markers were analyzed. Additionally we evaluated endothelin (ET)-1, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, activated protein C-protein C inhibitor (APC-PCI) complex, and CD40 ligand. Groups were compared with the Kruskall-Wallis test and the Mann-Whitney U test. Results: Of routine markers platelet count was lower (p=0.0006) and creatinine level was higher (p=0.028) in patients with large AAA. Almost all non-routine markers analyzed were highly elevated in AAA-patients compared to the control group. IL-6 (p=0.0002) and thrombin activation measured as APC-PCI (p<0.0001) increased depending on the size of AAA. Conclusion: Many of the analyzed biomarkers were markedly increased in AAA-patients and some were also related to aneurysm size. Whether any of the markers is also associated with aneurysm growth rate should be further evaluated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cytokine
volume
46
pages
211 - 215
publisher
Academic Press
external identifiers
  • WOS:000266346800010
  • PMID:19251434
  • Scopus:65049092330
ISSN
1096-0023
DOI
10.1016/j.cyto.2009.01.007
language
English
LU publication?
yes
id
63fc5e14-511d-4297-88ed-8ccc915baf61 (old id 1368113)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19251434?dopt=Abstract
date added to LUP
2009-04-03 12:27:00
date last changed
2016-10-13 04:28:14
@misc{63fc5e14-511d-4297-88ed-8ccc915baf61,
  abstract     = {Objective: The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth. Material and methods: Prospectively 360 AAA-patients and an age and sex-matched healthy control group (n=219) were analyzed. AAA-patients were divided in three groups according to AAA-diameter (small &lt;45mm, n=122, medium 45-55mm, n=108, and large &gt;55mm, n=130). Associated diseases, blood pressures and routine laboratory markers were analyzed. Additionally we evaluated endothelin (ET)-1, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, activated protein C-protein C inhibitor (APC-PCI) complex, and CD40 ligand. Groups were compared with the Kruskall-Wallis test and the Mann-Whitney U test. Results: Of routine markers platelet count was lower (p=0.0006) and creatinine level was higher (p=0.028) in patients with large AAA. Almost all non-routine markers analyzed were highly elevated in AAA-patients compared to the control group. IL-6 (p=0.0002) and thrombin activation measured as APC-PCI (p&lt;0.0001) increased depending on the size of AAA. Conclusion: Many of the analyzed biomarkers were markedly increased in AAA-patients and some were also related to aneurysm size. Whether any of the markers is also associated with aneurysm growth rate should be further evaluated.},
  author       = {Flondell-Sité, Despina and Lindblad, Bengt and Kölbel, Tilo and Gottsäter, Anders},
  issn         = {1096-0023},
  language     = {eng},
  pages        = {211--215},
  publisher    = {ARRAY(0x6558b70)},
  series       = {Cytokine},
  title        = {Cytokines and systemic biomarkers are related to the size of abdominal aortic aneurysms.},
  url          = {http://dx.doi.org/10.1016/j.cyto.2009.01.007},
  volume       = {46},
  year         = {2009},
}