Low Serum Testosterone and Estradiol Predict Mortality in Elderly Men.
(2009) In The Journal of clinical endocrinology and metabolism 94. p.2482-2488- Abstract
- Context: Age-related reduction of serum testosterone may contribute to the signs and symptoms of aging, but previous studies report conflicting evidence about testosterone levels and male mortality. No large prospective cohort study has determined a possible association between serum estradiol and mortality in men. Objective: The main objective was to examine the association between serum testosterone and estradiol and all-cause mortality in elderly men. Design, setting and participants: We used specific gas chromatography-mass spectrometry to analyze serum sex steroids at baseline in older men who participated in the prospective population-based MrOS Sweden cohort (n=3,014, mean 75 years of age, range 69-80). Main outcome measure:... (More)
- Context: Age-related reduction of serum testosterone may contribute to the signs and symptoms of aging, but previous studies report conflicting evidence about testosterone levels and male mortality. No large prospective cohort study has determined a possible association between serum estradiol and mortality in men. Objective: The main objective was to examine the association between serum testosterone and estradiol and all-cause mortality in elderly men. Design, setting and participants: We used specific gas chromatography-mass spectrometry to analyze serum sex steroids at baseline in older men who participated in the prospective population-based MrOS Sweden cohort (n=3,014, mean 75 years of age, range 69-80). Main outcome measure: All-cause mortality by serum testosterone and estradiol levels. Results: During a mean follow-up period of 4.5 years, 383 deaths occurred. In multivariate hazards regression models, low levels (within quartile 1; versus quartiles 2-4) of both testosterone (hazard ratio [HR] 1.65, 95% confidence interval [CI] 1.29-2.12) and estradiol (HR 1.54, 95% CI 1.22-1.95) associated with mortality. A model including both hormones showed that both low testosterone (HR 1.46, 95% CI 1.11-1.92) and estradiol (HR 1.33, 95% CI 1.02-1.73) predicted mortality. Risk of death nearly doubled (HR 1.96, 95% CI 1.46-2.62) in subjects with low levels of both testosterone and estradiol compared with subjects within quartiles 2-4 of both hormones. Conclusions: Elderly men with low serum testosterone and estradiol have increased risk of mortality, and subjects with low values of both testosterone and estradiol have the highest risk of mortality. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1391780
- author
- Tivesten, Asa ; Vandenput, Liesbeth ; Labrie, Fernand ; Karlsson, Magnus LU ; Ljunggren, Osten ; Mellström, Dan and Ohlsson, Claes
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 94
- pages
- 2482 - 2488
- publisher
- Oxford University Press
- external identifiers
-
- wos:000267767500043
- pmid:19401373
- scopus:67650248724
- pmid:19401373
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2008-2650
- language
- English
- LU publication?
- yes
- id
- 4eb72879-7447-46f5-a126-147de279a5e2 (old id 1391780)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19401373?dopt=Abstract
- date added to LUP
- 2016-04-04 09:38:48
- date last changed
- 2022-04-08 03:57:44
@article{4eb72879-7447-46f5-a126-147de279a5e2,
abstract = {{Context: Age-related reduction of serum testosterone may contribute to the signs and symptoms of aging, but previous studies report conflicting evidence about testosterone levels and male mortality. No large prospective cohort study has determined a possible association between serum estradiol and mortality in men. Objective: The main objective was to examine the association between serum testosterone and estradiol and all-cause mortality in elderly men. Design, setting and participants: We used specific gas chromatography-mass spectrometry to analyze serum sex steroids at baseline in older men who participated in the prospective population-based MrOS Sweden cohort (n=3,014, mean 75 years of age, range 69-80). Main outcome measure: All-cause mortality by serum testosterone and estradiol levels. Results: During a mean follow-up period of 4.5 years, 383 deaths occurred. In multivariate hazards regression models, low levels (within quartile 1; versus quartiles 2-4) of both testosterone (hazard ratio [HR] 1.65, 95% confidence interval [CI] 1.29-2.12) and estradiol (HR 1.54, 95% CI 1.22-1.95) associated with mortality. A model including both hormones showed that both low testosterone (HR 1.46, 95% CI 1.11-1.92) and estradiol (HR 1.33, 95% CI 1.02-1.73) predicted mortality. Risk of death nearly doubled (HR 1.96, 95% CI 1.46-2.62) in subjects with low levels of both testosterone and estradiol compared with subjects within quartiles 2-4 of both hormones. Conclusions: Elderly men with low serum testosterone and estradiol have increased risk of mortality, and subjects with low values of both testosterone and estradiol have the highest risk of mortality.}},
author = {{Tivesten, Asa and Vandenput, Liesbeth and Labrie, Fernand and Karlsson, Magnus and Ljunggren, Osten and Mellström, Dan and Ohlsson, Claes}},
issn = {{1945-7197}},
language = {{eng}},
pages = {{2482--2488}},
publisher = {{Oxford University Press}},
series = {{The Journal of clinical endocrinology and metabolism}},
title = {{Low Serum Testosterone and Estradiol Predict Mortality in Elderly Men.}},
url = {{http://dx.doi.org/10.1210/jc.2008-2650}},
doi = {{10.1210/jc.2008-2650}},
volume = {{94}},
year = {{2009}},
}