Advanced

Treatment of acute pancreatitis: focus on medical care.

Andersson, Roland LU ; Swärd, Anna LU ; Tingstedt, Bobby LU and Åkerberg, Daniel LU (2009) In Drugs 69(5). p.505-514
Abstract
Acute pancreatitis has an incidence of about 300 per 1 million individuals per year, of which 10-15% of patients develop the severe form of the disease. Novel management options, which have the potential to improve outcome, include initial proper fluid resuscitation, which maintains microcirculation and thereby potentially decreases ischaemia and reperfusion injury. The traditional treatment concept in acute pancreatitis, fasting and parenteral nutrition, has been challenged and early initiation of enteral feeding in severe pancreatitis and oral intake in mild acute pancreatitis is both feasible and provides some benefits. There are at present no data supporting immunonutritional supplements and probiotics should be avoided in patients... (More)
Acute pancreatitis has an incidence of about 300 per 1 million individuals per year, of which 10-15% of patients develop the severe form of the disease. Novel management options, which have the potential to improve outcome, include initial proper fluid resuscitation, which maintains microcirculation and thereby potentially decreases ischaemia and reperfusion injury. The traditional treatment concept in acute pancreatitis, fasting and parenteral nutrition, has been challenged and early initiation of enteral feeding in severe pancreatitis and oral intake in mild acute pancreatitis is both feasible and provides some benefits. There are at present no data supporting immunonutritional supplements and probiotics should be avoided in patients with acute pancreatitis. There is also no evidence of any benefits provided by prophylactic antibacterials in patients with predicted severe acute pancreatitis. A variety of specific medical interventions have been investigated (e.g. intense blood glucose monitoring by insulin) but none has become clinically useful. Lessons can probably be learned from critical care in general, but studies are needed to verify these interventions in acute pancreatitis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drugs
volume
69
issue
5
pages
505 - 514
publisher
Adis International
external identifiers
  • WOS:000266521800001
  • PMID:19368414
ISSN
0012-6667
language
English
LU publication?
yes
id
0bd24645-3296-412b-b344-e246c412f1f1 (old id 1392065)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19368414?dopt=Abstract
date added to LUP
2009-05-05 15:46:17
date last changed
2016-04-16 06:48:32
@misc{0bd24645-3296-412b-b344-e246c412f1f1,
  abstract     = {Acute pancreatitis has an incidence of about 300 per 1 million individuals per year, of which 10-15% of patients develop the severe form of the disease. Novel management options, which have the potential to improve outcome, include initial proper fluid resuscitation, which maintains microcirculation and thereby potentially decreases ischaemia and reperfusion injury. The traditional treatment concept in acute pancreatitis, fasting and parenteral nutrition, has been challenged and early initiation of enteral feeding in severe pancreatitis and oral intake in mild acute pancreatitis is both feasible and provides some benefits. There are at present no data supporting immunonutritional supplements and probiotics should be avoided in patients with acute pancreatitis. There is also no evidence of any benefits provided by prophylactic antibacterials in patients with predicted severe acute pancreatitis. A variety of specific medical interventions have been investigated (e.g. intense blood glucose monitoring by insulin) but none has become clinically useful. Lessons can probably be learned from critical care in general, but studies are needed to verify these interventions in acute pancreatitis.},
  author       = {Andersson, Roland and Swärd, Anna and Tingstedt, Bobby and Åkerberg, Daniel},
  issn         = {0012-6667},
  language     = {eng},
  number       = {5},
  pages        = {505--514},
  publisher    = {ARRAY(0xc3284a8)},
  series       = {Drugs},
  title        = {Treatment of acute pancreatitis: focus on medical care.},
  volume       = {69},
  year         = {2009},
}