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Malignt neuroleptikasyndrom--sällsynt diagnos med hög dödlighet.

Petersén, Åsa LU and Lundberg, Louise (2009) In Läkartidningen 106(18-19). p.1273-1276
Abstract
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal condition characterised by increased body temperature and muscle rigidity in a patient receiving antipsychotic treatment. Diagnosis also requires the presence of two symptoms of autonomic dysfunction and/or leukocytosis and increased creatin kinase. All neuroleptics, including atypical agents, can cause the condition, which is thought to arise from dopamine receptor blockade in the striatum and hypothalamus. Treatment includes withdrawal of the antipsychotic agent, intensive care, and pharmacological therapy with bensodiazepines, bromocriptine and dantrolene, as well as ECT in refractory cases. Significant differential diagnoses are encephalitis, serotonin syndrome, and... (More)
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal condition characterised by increased body temperature and muscle rigidity in a patient receiving antipsychotic treatment. Diagnosis also requires the presence of two symptoms of autonomic dysfunction and/or leukocytosis and increased creatin kinase. All neuroleptics, including atypical agents, can cause the condition, which is thought to arise from dopamine receptor blockade in the striatum and hypothalamus. Treatment includes withdrawal of the antipsychotic agent, intensive care, and pharmacological therapy with bensodiazepines, bromocriptine and dantrolene, as well as ECT in refractory cases. Significant differential diagnoses are encephalitis, serotonin syndrome, and lethal catatonia. It is thought that NMS, serotonin syndrome, and lethal catatonia constitute a spectrum of a neurobiological condition characterised by dopaminergic hypofunction as well as serotoninergic hyperfunction. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Catatonia: diagnosis, Neuroleptic Malignant Syndrome: diagnosis, Serotonin Syndrome: diagnosis, Neuroleptic Malignant Syndrome: mortality, Neuroleptic Malignant Syndrome: complications
in
Läkartidningen
volume
106
issue
18-19
pages
1273 - 1276
publisher
Sveriges Läkarförbund
external identifiers
  • PMID:19537499
  • Scopus:67549093399
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
44bfb39a-5c5b-4573-94df-5f5882398489 (old id 1434132)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19537499?dopt=Abstract
http://ltarkiv.lakartidningen.se/artNo36525
date added to LUP
2009-07-03 16:49:41
date last changed
2016-10-13 04:31:06
@misc{44bfb39a-5c5b-4573-94df-5f5882398489,
  abstract     = {Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal condition characterised by increased body temperature and muscle rigidity in a patient receiving antipsychotic treatment. Diagnosis also requires the presence of two symptoms of autonomic dysfunction and/or leukocytosis and increased creatin kinase. All neuroleptics, including atypical agents, can cause the condition, which is thought to arise from dopamine receptor blockade in the striatum and hypothalamus. Treatment includes withdrawal of the antipsychotic agent, intensive care, and pharmacological therapy with bensodiazepines, bromocriptine and dantrolene, as well as ECT in refractory cases. Significant differential diagnoses are encephalitis, serotonin syndrome, and lethal catatonia. It is thought that NMS, serotonin syndrome, and lethal catatonia constitute a spectrum of a neurobiological condition characterised by dopaminergic hypofunction as well as serotoninergic hyperfunction.},
  author       = {Petersén, Åsa and Lundberg, Louise},
  issn         = {0023-7205},
  keyword      = {Catatonia: diagnosis,Neuroleptic Malignant Syndrome: diagnosis,Serotonin Syndrome: diagnosis,Neuroleptic Malignant Syndrome: mortality,Neuroleptic Malignant Syndrome: complications},
  language     = {swe},
  number       = {18-19},
  pages        = {1273--1276},
  publisher    = {ARRAY(0xae04158)},
  series       = {Läkartidningen},
  title        = {Malignt neuroleptikasyndrom--sällsynt diagnos med hög dödlighet.},
  volume       = {106},
  year         = {2009},
}