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Bleeding peptic ulcer - time trends in incidence, treatment and mortality in Sweden.

Sadic, Jalal LU ; Borgström, Anders LU ; Manjer, Jonas LU ; Toth, Ervin LU and Lindell, Gert LU (2009) In Alimentary pharmacology & therapeutics 30. p.392-398
Abstract
Abstract Background: The incidence of peptic ulcer disease was expected to decrease following the introduction of acid inhibitors and H. pylori eradication. Aim: This study analyses possible changes in the incidence of bleeding peptic ulcer, treatment and mortality over time. Methods: Residents of Malmö hospitalised for bleeding gastric or duodenal ulcer disease1987-2004 were identified in hospital databases (n=1610). The material was divided in 6-year periods in order to identify changes over time. All patients who had been submitted to emergency surgery (n=137) were reviewed. Results: The incidence rate for bleeding gastric or duodenal ulcers decreased by one half in males and by one third in females and emergency operations decreased... (More)
Abstract Background: The incidence of peptic ulcer disease was expected to decrease following the introduction of acid inhibitors and H. pylori eradication. Aim: This study analyses possible changes in the incidence of bleeding peptic ulcer, treatment and mortality over time. Methods: Residents of Malmö hospitalised for bleeding gastric or duodenal ulcer disease1987-2004 were identified in hospital databases (n=1610). The material was divided in 6-year periods in order to identify changes over time. All patients who had been submitted to emergency surgery (n=137) were reviewed. Results: The incidence rate for bleeding gastric or duodenal ulcers decreased by one half in males and by one third in females and emergency operations decreased significantly (9.2, 7.5 and 5.7% during the three time periods respectively (p<0.05). The postoperative mortality tended to decrease (9.7, 2.4 and 3.7% respectively) and the 30-day mortality rates in the whole material were 1.2, 3.6 and 3.4% during the different time periods. Conclusion: The incidence of bleeding gastric and duodenal ulcer disease has decreased markedly. Operative treatment has been replaced by endoscopic treatment. The bleeding ulcer related mortality was less than 4% and has not changed over time. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alimentary pharmacology & therapeutics
volume
30
pages
392 - 398
publisher
Wiley-Blackwell
external identifiers
  • WOS:000268166300008
  • PMID:19508403
  • Scopus:67651162335
ISSN
1365-2036
DOI
10.1111/j.1365-2036.2009.04058.x
language
English
LU publication?
yes
id
679db63a-c438-424b-987c-539b89b2a856 (old id 1434377)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19508403?dopt=Abstract
date added to LUP
2009-07-03 14:47:19
date last changed
2016-10-13 04:32:03
@misc{679db63a-c438-424b-987c-539b89b2a856,
  abstract     = {Abstract Background: The incidence of peptic ulcer disease was expected to decrease following the introduction of acid inhibitors and H. pylori eradication. Aim: This study analyses possible changes in the incidence of bleeding peptic ulcer, treatment and mortality over time. Methods: Residents of Malmö hospitalised for bleeding gastric or duodenal ulcer disease1987-2004 were identified in hospital databases (n=1610). The material was divided in 6-year periods in order to identify changes over time. All patients who had been submitted to emergency surgery (n=137) were reviewed. Results: The incidence rate for bleeding gastric or duodenal ulcers decreased by one half in males and by one third in females and emergency operations decreased significantly (9.2, 7.5 and 5.7% during the three time periods respectively (p&lt;0.05). The postoperative mortality tended to decrease (9.7, 2.4 and 3.7% respectively) and the 30-day mortality rates in the whole material were 1.2, 3.6 and 3.4% during the different time periods. Conclusion: The incidence of bleeding gastric and duodenal ulcer disease has decreased markedly. Operative treatment has been replaced by endoscopic treatment. The bleeding ulcer related mortality was less than 4% and has not changed over time.},
  author       = {Sadic, Jalal and Borgström, Anders and Manjer, Jonas and Toth, Ervin and Lindell, Gert},
  issn         = {1365-2036},
  language     = {eng},
  pages        = {392--398},
  publisher    = {ARRAY(0xa5f9800)},
  series       = {Alimentary pharmacology & therapeutics},
  title        = {Bleeding peptic ulcer - time trends in incidence, treatment and mortality in Sweden.},
  url          = {http://dx.doi.org/10.1111/j.1365-2036.2009.04058.x},
  volume       = {30},
  year         = {2009},
}