Advanced

Early rheumatoid arthritis and body composition.

Book, Christina LU ; Karlsson, Magnus LU ; Åkesson, Kristina LU and Jacobsson, Lennart LU (2009) In Rheumatology (Oxford, England) 48. p.1128-1132
Abstract
Objectives. RA is associated with joint destruction and cardiovascular diseases (CVDs). Possible predictors for CVD are early changes in body composition. We therefore evaluated whether lean mass of arms and legs (LMAL), total body fat mass (BFM) or truncal fat distribution (TFD) are altered early in RA, and if so, which factors are associated. Methods. We included 132 RA patients (95 women) with disease duration of </=12 months. Disease activity score (DAS28), HAQ, BMI, comorbidity, smoking and medications were recorded. Total and regional lean mass and fat mass were measured with DXA. Data were compared with 132 age- and gender-matched controls, and possibly associated factors were analysed in linear regression models. Results. LMAL... (More)
Objectives. RA is associated with joint destruction and cardiovascular diseases (CVDs). Possible predictors for CVD are early changes in body composition. We therefore evaluated whether lean mass of arms and legs (LMAL), total body fat mass (BFM) or truncal fat distribution (TFD) are altered early in RA, and if so, which factors are associated. Methods. We included 132 RA patients (95 women) with disease duration of </=12 months. Disease activity score (DAS28), HAQ, BMI, comorbidity, smoking and medications were recorded. Total and regional lean mass and fat mass were measured with DXA. Data were compared with 132 age- and gender-matched controls, and possibly associated factors were analysed in linear regression models. Results. LMAL was low in patients for both women and men (P = 0.007 and <0.001, respectively). BMI (P = 0.012), BFM (P = 0.014) and TFD (P < 0.001) were higher than expected in RA women. In bivariate analyses, all adjusted for age and current smoking, disease duration was independently associated with low LMAL in women (P = 0.021). High BFM was associated with HAQ x disease duration in men (P = 0.033) and DAS28 in women (P = 0.011). High TFD was associated with a history of diabetes or CVD in men with RA (P = 0.005). Conclusions. Low LMAL, high BFM and high TFD are present in early RA patients. The long-term significant consequences of these abnormalities need to be determined. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology (Oxford, England)
volume
48
pages
1128 - 1132
publisher
Oxford University Press
external identifiers
  • WOS:000270133800022
  • PMID:19602478
  • Scopus:70349785460
ISSN
1462-0332
DOI
10.1093/rheumatology/kep165
language
English
LU publication?
yes
id
369596b2-de86-459c-a83e-83f801d3d405 (old id 1453094)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19602478?dopt=Abstract
date added to LUP
2009-08-04 11:28:24
date last changed
2016-10-30 04:33:47
@misc{369596b2-de86-459c-a83e-83f801d3d405,
  abstract     = {Objectives. RA is associated with joint destruction and cardiovascular diseases (CVDs). Possible predictors for CVD are early changes in body composition. We therefore evaluated whether lean mass of arms and legs (LMAL), total body fat mass (BFM) or truncal fat distribution (TFD) are altered early in RA, and if so, which factors are associated. Methods. We included 132 RA patients (95 women) with disease duration of &lt;/=12 months. Disease activity score (DAS28), HAQ, BMI, comorbidity, smoking and medications were recorded. Total and regional lean mass and fat mass were measured with DXA. Data were compared with 132 age- and gender-matched controls, and possibly associated factors were analysed in linear regression models. Results. LMAL was low in patients for both women and men (P = 0.007 and &lt;0.001, respectively). BMI (P = 0.012), BFM (P = 0.014) and TFD (P &lt; 0.001) were higher than expected in RA women. In bivariate analyses, all adjusted for age and current smoking, disease duration was independently associated with low LMAL in women (P = 0.021). High BFM was associated with HAQ x disease duration in men (P = 0.033) and DAS28 in women (P = 0.011). High TFD was associated with a history of diabetes or CVD in men with RA (P = 0.005). Conclusions. Low LMAL, high BFM and high TFD are present in early RA patients. The long-term significant consequences of these abnormalities need to be determined.},
  author       = {Book, Christina and Karlsson, Magnus and Åkesson, Kristina and Jacobsson, Lennart},
  issn         = {1462-0332},
  language     = {eng},
  pages        = {1128--1132},
  publisher    = {ARRAY(0x91f6288)},
  series       = {Rheumatology (Oxford, England)},
  title        = {Early rheumatoid arthritis and body composition.},
  url          = {http://dx.doi.org/10.1093/rheumatology/kep165},
  volume       = {48},
  year         = {2009},
}