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Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome.

Fava, Cristiano LU ; Montagnana, Martina LU ; Guerriero, Massimo; Almgren, Peter LU ; von Wowern, Fredrik; Minuz, Pietro and Melander, Olle LU (2009) In Journal of Hypertension 27. p.1794-1803
Abstract
OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'.... (More)
OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'. Successively, the I/D polymorphism of the ADRA2B gene was genotyped in 5283 patients in the Malmö Diet and Cancer-cardiovascular arm, seeking for association with the MetS using standard definitions and separately, with its individual components. RESULTS: For 24-h pulse pressure and waist/hip ratio, LOD [logarithm of the odds (to the base 10)] scores of more than two were found between 107 and 122 cM on chromosome 2. For the composite sum of MetS phenotypes, LOD score of more than 1 was found between 116 and 120 cM. There was no difference between carriers and noncarriers of the D-allele of the ADRA2B gene in MetS prevalence but D-carriers were associated with significantly higher levels of diastolic blood pressure. CONCLUSION: Our results suggest that chromosome 2 could harbor one or more genes implied in blood pressure homeostasis and MetS development. The ADRA2B I/D polymorphism is not consistently associated with MetS and metabolic/anthropometric parameters but with diastolic blood pressure in an urban-based population of middle-aged Swedes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
27
pages
1794 - 1803
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000269549500012
  • PMID:19593211
  • Scopus:73249130357
ISSN
1473-5598
DOI
10.1097/HJH.0b013e32832d3f9c
language
English
LU publication?
yes
id
1d058ef1-dc5e-41f3-81e5-aca334d55f62 (old id 1453150)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19593211?dopt=Abstract
date added to LUP
2009-08-04 11:43:51
date last changed
2016-10-13 04:24:07
@misc{1d058ef1-dc5e-41f3-81e5-aca334d55f62,
  abstract     = {OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'. Successively, the I/D polymorphism of the ADRA2B gene was genotyped in 5283 patients in the Malmö Diet and Cancer-cardiovascular arm, seeking for association with the MetS using standard definitions and separately, with its individual components. RESULTS: For 24-h pulse pressure and waist/hip ratio, LOD [logarithm of the odds (to the base 10)] scores of more than two were found between 107 and 122 cM on chromosome 2. For the composite sum of MetS phenotypes, LOD score of more than 1 was found between 116 and 120 cM. There was no difference between carriers and noncarriers of the D-allele of the ADRA2B gene in MetS prevalence but D-carriers were associated with significantly higher levels of diastolic blood pressure. CONCLUSION: Our results suggest that chromosome 2 could harbor one or more genes implied in blood pressure homeostasis and MetS development. The ADRA2B I/D polymorphism is not consistently associated with MetS and metabolic/anthropometric parameters but with diastolic blood pressure in an urban-based population of middle-aged Swedes.},
  author       = {Fava, Cristiano and Montagnana, Martina and Guerriero, Massimo and Almgren, Peter and von Wowern, Fredrik and Minuz, Pietro and Melander, Olle},
  issn         = {1473-5598},
  language     = {eng},
  pages        = {1794--1803},
  publisher    = {ARRAY(0x9d63578)},
  series       = {Journal of Hypertension},
  title        = {Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e32832d3f9c},
  volume       = {27},
  year         = {2009},
}