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Association between tumor tissue TIMP-1 levels and objective response to first-line chemotherapy in metastatic breast cancer.

Klintman, Marie LU ; Ornbjerg Würtz, Sidse; Christensen, Ib; Bræmer Hertel, Pernille; Fernö, Mårten LU ; Malmberg, Martin; Mouridsen, Henning; Cold, Frederik; Schrohl, Anne-Sofie and Foekens, John, et al. (2010) In Breast Cancer Research and Treatment 121. p.365-371
Abstract
In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the association between TIMP-1 and objective response to chemotherapy in an independent patient population consisting of patients with metastatic breast cancer from Sweden and Denmark. TIMP-1 was measured using ELISA in 162 primary tumor extracts from patients who later developed metastatic breast cancer and these levels were related to the objective response to first-line chemotherapy.... (More)
In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the association between TIMP-1 and objective response to chemotherapy in an independent patient population consisting of patients with metastatic breast cancer from Sweden and Denmark. TIMP-1 was measured using ELISA in 162 primary tumor extracts from patients who later developed metastatic breast cancer and these levels were related to the objective response to first-line chemotherapy. Increasing levels of TIMP-1 were associated with a decreasing probability of response to treatment, reaching borderline significance (OR = 1.59, 95% CI: 0.97-2.62, P = 0.07). This OR is very similar to the result from our previous study. Increasing levels of TIMP-1 were also associated with a shorter disease-free survival and overall survival, however, not statistically significant. The results from the present study support previous data that TIMP-1 is associated with objective response to chemotherapy for metastatic breast cancer. (Less)
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publication status
published
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Breast Cancer Research and Treatment
volume
121
pages
365 - 371
publisher
Springer
external identifiers
  • WOS:000277906500011
  • PMID:19653096
  • Scopus:77953020152
ISSN
1573-7217
DOI
10.1007/s10549-009-0483-1
language
English
LU publication?
yes
id
84ccbdc3-5858-4b6e-ae97-9c45fedb6f1c (old id 1470053)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19653096?dopt=Abstract
date added to LUP
2009-09-04 11:04:09
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2016-10-13 04:33:30
@misc{84ccbdc3-5858-4b6e-ae97-9c45fedb6f1c,
  abstract     = {In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the association between TIMP-1 and objective response to chemotherapy in an independent patient population consisting of patients with metastatic breast cancer from Sweden and Denmark. TIMP-1 was measured using ELISA in 162 primary tumor extracts from patients who later developed metastatic breast cancer and these levels were related to the objective response to first-line chemotherapy. Increasing levels of TIMP-1 were associated with a decreasing probability of response to treatment, reaching borderline significance (OR = 1.59, 95% CI: 0.97-2.62, P = 0.07). This OR is very similar to the result from our previous study. Increasing levels of TIMP-1 were also associated with a shorter disease-free survival and overall survival, however, not statistically significant. The results from the present study support previous data that TIMP-1 is associated with objective response to chemotherapy for metastatic breast cancer.},
  author       = {Klintman, Marie and Ornbjerg Würtz, Sidse and Christensen, Ib and Bræmer Hertel, Pernille and Fernö, Mårten and Malmberg, Martin and Mouridsen, Henning and Cold, Frederik and Schrohl, Anne-Sofie and Foekens, John and Malmström, Per and Brünner, Nils},
  issn         = {1573-7217},
  language     = {eng},
  pages        = {365--371},
  publisher    = {ARRAY(0x958fb38)},
  series       = {Breast Cancer Research and Treatment},
  title        = {Association between tumor tissue TIMP-1 levels and objective response to first-line chemotherapy in metastatic breast cancer.},
  url          = {http://dx.doi.org/10.1007/s10549-009-0483-1},
  volume       = {121},
  year         = {2010},
}