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No Risk of Maternal EBV Infection for Childhood Leukemia.

Tedeschi, Rosamaria; Luostarinen, Tapio; Marus, Alessia; Bzhalava, Davit; Ogmundsdottir, Helga M; Dillner, Joakim LU ; De Paoli, Paolo; Surcel, Heljä-Marja; Pukkala, Eero and Lehtinen, Matti, et al. (2009) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 18. p.2790-2792
Abstract
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified through national cancer registries. For each index mother of a leukemia case, three matched control mothers with cancer-free offspring were identified. First trimester sera from 561 ALL and 144 non-ALL index mothers and from 2,105 control mothers were analyzed for antibodies to EBV viral capsid antigen (IgG and IgM), early antigen (IgG) and ZEBRA... (More)
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified through national cancer registries. For each index mother of a leukemia case, three matched control mothers with cancer-free offspring were identified. First trimester sera from 561 ALL and 144 non-ALL index mothers and from 2,105 control mothers were analyzed for antibodies to EBV viral capsid antigen (IgG and IgM), early antigen (IgG) and ZEBRA protein (IgG). Conditional logistic regression-based estimates of odds ratios and 95% confidence intervals adjusted for birth order and sib-ship size were calculated. Overall, there was no evidence of increased risk of ALL associated to EBV viral capsid antigen IgM (odds ratio, 0.9; 95% confidence interval, 0.5-1.8). The early antigen and ZEBRA antibodies (EBV reactivation markers) were also not associated with risk. The data argue against a role of EBV in ALL. (Cancer Epidemiol Biomarkers Prev 2009;18(10):OF1-3). (Less)
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
volume
18
pages
2790 - 2792
publisher
American Association for Cancer Research
external identifiers
  • WOS:000270702100030
  • PMID:19755652
  • Scopus:70350103717
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-09-0751
language
English
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yes
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db15e431-e8c2-4c1a-bcfa-42620a6e4357 (old id 1483454)
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http://www.ncbi.nlm.nih.gov/pubmed/19755652?dopt=Abstract
date added to LUP
2009-10-07 12:23:24
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2016-11-01 09:54:57
@misc{db15e431-e8c2-4c1a-bcfa-42620a6e4357,
  abstract     = {We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified through national cancer registries. For each index mother of a leukemia case, three matched control mothers with cancer-free offspring were identified. First trimester sera from 561 ALL and 144 non-ALL index mothers and from 2,105 control mothers were analyzed for antibodies to EBV viral capsid antigen (IgG and IgM), early antigen (IgG) and ZEBRA protein (IgG). Conditional logistic regression-based estimates of odds ratios and 95% confidence intervals adjusted for birth order and sib-ship size were calculated. Overall, there was no evidence of increased risk of ALL associated to EBV viral capsid antigen IgM (odds ratio, 0.9; 95% confidence interval, 0.5-1.8). The early antigen and ZEBRA antibodies (EBV reactivation markers) were also not associated with risk. The data argue against a role of EBV in ALL. (Cancer Epidemiol Biomarkers Prev 2009;18(10):OF1-3).},
  author       = {Tedeschi, Rosamaria and Luostarinen, Tapio and Marus, Alessia and Bzhalava, Davit and Ogmundsdottir, Helga M and Dillner, Joakim and De Paoli, Paolo and Surcel, Heljä-Marja and Pukkala, Eero and Lehtinen, Matti and Lehtinen, Tuula},
  issn         = {1538-7755},
  language     = {eng},
  pages        = {2790--2792},
  publisher    = {ARRAY(0x4bd8920)},
  series       = {Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  title        = {No Risk of Maternal EBV Infection for Childhood Leukemia.},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-09-0751},
  volume       = {18},
  year         = {2009},
}