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Long-term psychological effects of carrier testing and prenatal diagnosis of haemophilia: Comparison with a control group

Tedgård, U. LU ; Ljung, R. LU and McNeil, T.F. LU (1999) In Prenatal Diagnosis 19(5). p.411-417
Abstract
The long-term psychological effects resulting from carrier testing and prenatal diagnosis (PD) of haemophilia were evaluated by comparing mental symptomatology scores (Symptom Check List, SCL-90) for 50 carriers of haemophilia who had undergone PD about five years earlier, 55 carriers who had not undergone PD and 262 control women who were not carriers. All of the women had children. Carrier testing for haemophilia per se and in combination with PD does not appear to have negative long-term psychological effects. A low tendency for somatization seems to be a factor characteristic of carriers considering PD for haemophilia and it was particularly salient when carriers had to consider the more invasive late PD procedures (amniocentesis and... (More)
The long-term psychological effects resulting from carrier testing and prenatal diagnosis (PD) of haemophilia were evaluated by comparing mental symptomatology scores (Symptom Check List, SCL-90) for 50 carriers of haemophilia who had undergone PD about five years earlier, 55 carriers who had not undergone PD and 262 control women who were not carriers. All of the women had children. Carrier testing for haemophilia per se and in combination with PD does not appear to have negative long-term psychological effects. A low tendency for somatization seems to be a factor characteristic of carriers considering PD for haemophilia and it was particularly salient when carriers had to consider the more invasive late PD procedures (amniocentesis and fetal blood sampling). Women who performed late PD appeared to represent a positive selection of carriers for whom a good sense of coherence and social support protected them from negative long-term psychological effects. It is reassuring that early PD by CVS, which is the current method of choice for PD for haemophilia, did not appear to have negative long-term psychological effects, even for women who had had an early abortion following PD. (Less)
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organization
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Contribution to journal
publication status
published
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keywords
Carrier testing, Follow-up study, Haemophilia, Prenatal diagnosis, Psychology, abortion, adult, amniocentesis, article, chorion villus sampling, controlled study, female, fetus blood sampling, genetic screening, hemophilia, heterozygote, human, major clinical study, prenatal diagnosis, priority journal, psychology, social support, somatization, symptomatology
in
Prenatal Diagnosis
volume
19
issue
5
pages
7 pages
publisher
John Wiley and Sons Ltd
external identifiers
  • Scopus:0345189528
ISSN
1097-0223
language
English
LU publication?
yes
id
14889e52-7d06-441d-b253-3758f18dd3ba
date added to LUP
2016-11-25 14:21:57
date last changed
2016-11-30 10:09:06
@misc{14889e52-7d06-441d-b253-3758f18dd3ba,
  abstract     = {The long-term psychological effects resulting from carrier testing and prenatal diagnosis (PD) of haemophilia were evaluated by comparing mental symptomatology scores (Symptom Check List, SCL-90) for 50 carriers of haemophilia who had undergone PD about five years earlier, 55 carriers who had not undergone PD and 262 control women who were not carriers. All of the women had children. Carrier testing for haemophilia per se and in combination with PD does not appear to have negative long-term psychological effects. A low tendency for somatization seems to be a factor characteristic of carriers considering PD for haemophilia and it was particularly salient when carriers had to consider the more invasive late PD procedures (amniocentesis and fetal blood sampling). Women who performed late PD appeared to represent a positive selection of carriers for whom a good sense of coherence and social support protected them from negative long-term psychological effects. It is reassuring that early PD by CVS, which is the current method of choice for PD for haemophilia, did not appear to have negative long-term psychological effects, even for women who had had an early abortion following PD.},
  author       = {Tedgård, U. and Ljung, R. and McNeil, T.F.},
  issn         = {1097-0223},
  keyword      = {Carrier testing,Follow-up study,Haemophilia,Prenatal diagnosis,Psychology,abortion,adult,amniocentesis,article,chorion villus sampling,controlled study,female,fetus blood sampling,genetic screening,hemophilia,heterozygote,human,major clinical study,prenatal diagnosis,priority journal,psychology,social support,somatization,symptomatology},
  language     = {eng},
  month        = {11},
  number       = {5},
  pages        = {411--417},
  publisher    = {ARRAY(0x81552d0)},
  series       = {Prenatal Diagnosis},
  title        = {Long-term psychological effects of carrier testing and prenatal diagnosis of haemophilia: Comparison with a control group},
  volume       = {19},
  year         = {1999},
}