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Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men.

Movérare-Skrtic, Sofia; Svensson, Johan; Karlsson, Magnus LU ; Orwoll, Eric; Ljunggren, Osten; Mellström, Dan and Ohlsson, Claes (2009) In The Journal of clinical endocrinology and metabolism 94. p.5078-5084
Abstract
Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression... (More)
Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of clinical endocrinology and metabolism
volume
94
pages
5078 - 5084
publisher
The Endocrine Society
external identifiers
  • WOS:000272379400063
  • PMID:19846733
  • Scopus:73249128862
ISSN
1945-7197
DOI
10.1210/jc.2009-1450
language
English
LU publication?
yes
id
f1d15ad7-3a18-4002-b74b-9ab97605191a (old id 1500111)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19846733?dopt=Abstract
date added to LUP
2009-11-03 12:57:36
date last changed
2016-11-09 14:39:54
@misc{f1d15ad7-3a18-4002-b74b-9ab97605191a,
  abstract     = {Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P &lt; 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined.},
  author       = {Movérare-Skrtic, Sofia and Svensson, Johan and Karlsson, Magnus and Orwoll, Eric and Ljunggren, Osten and Mellström, Dan and Ohlsson, Claes},
  issn         = {1945-7197},
  language     = {eng},
  pages        = {5078--5084},
  publisher    = {ARRAY(0xb093a38)},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men.},
  url          = {http://dx.doi.org/10.1210/jc.2009-1450},
  volume       = {94},
  year         = {2009},
}