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Renal failure occurs in chronic lithium treatment but is uncommon.

Bendz, Hans LU ; Schön, Staffan; Attman, Per-Ola and Aurell, Mattias (2010) In Kidney International 77. p.219-224
Abstract
We sought to establish the prevalence of lithium-induced end-stage renal disease in two regions of Sweden with 2.7 million inhabitants corresponding to about 30% of the Swedish population. Eighteen patients with lithium-induced end-stage renal disease were identified among the 3369 patients in the general lithium-treated population, representing a sixfold increase in prevalence compared with the general population for renal replacement therapy. All lithium-treated patients were older than 46 years at end-stage renal disease with a mean lithium treatment time of 23 years with ten patients having discontinued lithium treatment an average of 10 years before the start of renal replacement therapy. The prevalence of chronic kidney disease... (More)
We sought to establish the prevalence of lithium-induced end-stage renal disease in two regions of Sweden with 2.7 million inhabitants corresponding to about 30% of the Swedish population. Eighteen patients with lithium-induced end-stage renal disease were identified among the 3369 patients in the general lithium-treated population, representing a sixfold increase in prevalence compared with the general population for renal replacement therapy. All lithium-treated patients were older than 46 years at end-stage renal disease with a mean lithium treatment time of 23 years with ten patients having discontinued lithium treatment an average of 10 years before the start of renal replacement therapy. The prevalence of chronic kidney disease (defined as plasma creatinine over 150 mumol/l) in the general lithium-treated population was about 1.2% (excluding patients on renal replacement therapy). Compared with lithium-treated patients without renal failure, those with chronic kidney disease were older and most were men but, as groups, their mean serum lithium levels and psychiatric diagnoses did not differ. We found that end-stage renal disease is an uncommon but not rare consequence of long-term lithium treatment and is more prevalent than previously thought. Time on lithium was the only identified risk factor in this study, suggesting that regular monitoring of renal function in these patients is mandatory.Kidney International advance online publication, 25 November 2009; doi:10.1038/ki.2009.433. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Kidney International
volume
77
pages
219 - 224
publisher
Nature Publishing Group
external identifiers
  • WOS:000273573000009
  • PMID:19940841
  • Scopus:74449090125
ISSN
1523-1755
DOI
10.1038/ki.2009.433
language
English
LU publication?
yes
id
971cfd5a-147e-449a-8849-e3183d13abd7 (old id 1511522)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19940841?dopt=Abstract
date added to LUP
2009-12-07 10:58:59
date last changed
2016-11-13 04:29:54
@misc{971cfd5a-147e-449a-8849-e3183d13abd7,
  abstract     = {We sought to establish the prevalence of lithium-induced end-stage renal disease in two regions of Sweden with 2.7 million inhabitants corresponding to about 30% of the Swedish population. Eighteen patients with lithium-induced end-stage renal disease were identified among the 3369 patients in the general lithium-treated population, representing a sixfold increase in prevalence compared with the general population for renal replacement therapy. All lithium-treated patients were older than 46 years at end-stage renal disease with a mean lithium treatment time of 23 years with ten patients having discontinued lithium treatment an average of 10 years before the start of renal replacement therapy. The prevalence of chronic kidney disease (defined as plasma creatinine over 150 mumol/l) in the general lithium-treated population was about 1.2% (excluding patients on renal replacement therapy). Compared with lithium-treated patients without renal failure, those with chronic kidney disease were older and most were men but, as groups, their mean serum lithium levels and psychiatric diagnoses did not differ. We found that end-stage renal disease is an uncommon but not rare consequence of long-term lithium treatment and is more prevalent than previously thought. Time on lithium was the only identified risk factor in this study, suggesting that regular monitoring of renal function in these patients is mandatory.Kidney International advance online publication, 25 November 2009; doi:10.1038/ki.2009.433.},
  author       = {Bendz, Hans and Schön, Staffan and Attman, Per-Ola and Aurell, Mattias},
  issn         = {1523-1755},
  language     = {eng},
  pages        = {219--224},
  publisher    = {ARRAY(0x9e3d458)},
  series       = {Kidney International},
  title        = {Renal failure occurs in chronic lithium treatment but is uncommon.},
  url          = {http://dx.doi.org/10.1038/ki.2009.433},
  volume       = {77},
  year         = {2010},
}