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Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.

Barany, George; Albericio, Fernando; Kates, Steven and Kempe, Maria LU (1997) In Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series 680. p.239-264
Abstract
The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the... (More)
The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
categories
Popular Science
in
Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series
editor
Harris, J.M. and Zalipsky, S.
volume
680
pages
239 - 264
publisher
The American Chemical Society
external identifiers
  • Scopus:0347800797
ISBN
9780841235373
DOI
10.1021/bk-1997-0680.ch017
language
English
LU publication?
yes
id
b5aff72d-47f5-4281-b59a-d5b2d281d730 (old id 1516124)
date added to LUP
2009-12-17 09:46:35
date last changed
2016-10-13 04:46:13
@misc{b5aff72d-47f5-4281-b59a-d5b2d281d730,
  abstract     = {The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives.},
  author       = {Barany, George and Albericio, Fernando and Kates, Steven and Kempe, Maria},
  editor       = {Harris, J.M. and Zalipsky, S.},
  isbn         = {9780841235373},
  language     = {eng},
  pages        = {239--264},
  publisher    = {ARRAY(0x897b5d8)},
  series       = {Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series},
  title        = {Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.},
  url          = {http://dx.doi.org/10.1021/bk-1997-0680.ch017},
  volume       = {680},
  year         = {1997},
}