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Ethnic Differences in Incidence of Type 1 Diabetes among Second-Generation Immigrants and Adoptees from Abroad.

Ji, Jianguang LU ; Hemminki, Kari LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2010) In The Journal of clinical endocrinology and metabolism 95. p.847-850
Abstract
Objective: The incidence of type 1 diabetes shows a large variation worldwide, but whether the causes are environmental or genetic has not been settled. We examine here the incidence of type 1 diabetes among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic vs. environmental influence, assuming adoptees from abroad have similar environmental exposures compared with the native Swedes, with the only difference in their genetic background. Methods: Second-generation immigrants and adoptees from abroad were retrieved from the MIGMED2 database, and they were followed up until the diagnosis of type 1 diabetes, death, or the end of study. Standardized incidence ratios (SIRs) were calculated for type 1 diabetes... (More)
Objective: The incidence of type 1 diabetes shows a large variation worldwide, but whether the causes are environmental or genetic has not been settled. We examine here the incidence of type 1 diabetes among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic vs. environmental influence, assuming adoptees from abroad have similar environmental exposures compared with the native Swedes, with the only difference in their genetic background. Methods: Second-generation immigrants and adoptees from abroad were retrieved from the MIGMED2 database, and they were followed up until the diagnosis of type 1 diabetes, death, or the end of study. Standardized incidence ratios (SIRs) were calculated for type 1 diabetes among these immigrants compared with native Swedes. Results: A total of 1,050,569 children were defined as second-generation immigrants and the overall SIR of type 1 diabetes was significantly decreased. A decreased risk was observed for all countries of origin, with an exception for children with parents from Finland. A total of 51,557 children born in foreign countries were adopted by Swedes. Adoptees from Eastern Europe, Soviet countries, India, Pakistan, Afghanistan, East and Southeast Asia, Chile, and other Central and South American countries had a significantly decreased SIR. Conclusions: The decreased incidence of type 1 diabetes observed in some second-generation immigrants and adoptees from abroad strongly suggests that ethnic genetic heterogeneity could play an important role on type 1 diabetes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of clinical endocrinology and metabolism
volume
95
pages
847 - 850
publisher
The Endocrine Society
external identifiers
  • WOS:000274298200048
  • PMID:20022988
  • Scopus:76149138455
ISSN
1945-7197
DOI
10.1210/jc.2009-1818
language
English
LU publication?
yes
id
7215359e-68d1-4ff9-92db-39f9a6f060e6 (old id 1523458)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20022988?dopt=Abstract
date added to LUP
2010-01-11 16:44:52
date last changed
2016-11-09 14:39:54
@misc{7215359e-68d1-4ff9-92db-39f9a6f060e6,
  abstract     = {Objective: The incidence of type 1 diabetes shows a large variation worldwide, but whether the causes are environmental or genetic has not been settled. We examine here the incidence of type 1 diabetes among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic vs. environmental influence, assuming adoptees from abroad have similar environmental exposures compared with the native Swedes, with the only difference in their genetic background. Methods: Second-generation immigrants and adoptees from abroad were retrieved from the MIGMED2 database, and they were followed up until the diagnosis of type 1 diabetes, death, or the end of study. Standardized incidence ratios (SIRs) were calculated for type 1 diabetes among these immigrants compared with native Swedes. Results: A total of 1,050,569 children were defined as second-generation immigrants and the overall SIR of type 1 diabetes was significantly decreased. A decreased risk was observed for all countries of origin, with an exception for children with parents from Finland. A total of 51,557 children born in foreign countries were adopted by Swedes. Adoptees from Eastern Europe, Soviet countries, India, Pakistan, Afghanistan, East and Southeast Asia, Chile, and other Central and South American countries had a significantly decreased SIR. Conclusions: The decreased incidence of type 1 diabetes observed in some second-generation immigrants and adoptees from abroad strongly suggests that ethnic genetic heterogeneity could play an important role on type 1 diabetes.},
  author       = {Ji, Jianguang and Hemminki, Kari and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1945-7197},
  language     = {eng},
  pages        = {847--850},
  publisher    = {ARRAY(0x88d4ea0)},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Ethnic Differences in Incidence of Type 1 Diabetes among Second-Generation Immigrants and Adoptees from Abroad.},
  url          = {http://dx.doi.org/10.1210/jc.2009-1818},
  volume       = {95},
  year         = {2010},
}