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The role of small leucine-rich proteoglycans in collagen fibrillogenesis.

Kalamajski, Sebastian LU and Oldberg, Åke LU (2010) In Matrix Biology 29. p.248-253
Abstract
Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices. SLRPs are differentially expressed in tissues and during pathological conditions, contributing to the development of connective tissue properties. The binding of SLRPs to collagens have recently been characterized, and may give some clues to the significance of these interactions. In this mini review, we summarize published work in this field, and propose several mechanisms for how SLRPs can control collagen matrix structure and function. SLRPs appear to influence collagen cross-linking patterns. We also propose that the SLRP-collagen interactions can assist in the... (More)
Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices. SLRPs are differentially expressed in tissues and during pathological conditions, contributing to the development of connective tissue properties. The binding of SLRPs to collagens have recently been characterized, and may give some clues to the significance of these interactions. In this mini review, we summarize published work in this field, and propose several mechanisms for how SLRPs can control collagen matrix structure and function. SLRPs appear to influence collagen cross-linking patterns. We also propose that the SLRP-collagen interactions can assist in the process of juxtaposing the collagen monomers by steric hindrance or by directly connecting two collagen monomers during the fibril growth. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Matrix Biology
volume
29
pages
248 - 253
publisher
Elsevier
external identifiers
  • WOS:000278307100002
  • PMID:20080181
  • Scopus:77952550108
ISSN
1569-1802
DOI
10.1016/j.matbio.2010.01.001
language
English
LU publication?
yes
id
efc21ecf-658d-4008-be2b-0e18368dac6c (old id 1541012)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20080181?dopt=Abstract
date added to LUP
2010-02-03 09:26:43
date last changed
2016-11-27 04:28:23
@misc{efc21ecf-658d-4008-be2b-0e18368dac6c,
  abstract     = {Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices. SLRPs are differentially expressed in tissues and during pathological conditions, contributing to the development of connective tissue properties. The binding of SLRPs to collagens have recently been characterized, and may give some clues to the significance of these interactions. In this mini review, we summarize published work in this field, and propose several mechanisms for how SLRPs can control collagen matrix structure and function. SLRPs appear to influence collagen cross-linking patterns. We also propose that the SLRP-collagen interactions can assist in the process of juxtaposing the collagen monomers by steric hindrance or by directly connecting two collagen monomers during the fibril growth.},
  author       = {Kalamajski, Sebastian and Oldberg, Åke},
  issn         = {1569-1802},
  language     = {eng},
  pages        = {248--253},
  publisher    = {ARRAY(0xa1cff28)},
  series       = {Matrix Biology},
  title        = {The role of small leucine-rich proteoglycans in collagen fibrillogenesis.},
  url          = {http://dx.doi.org/10.1016/j.matbio.2010.01.001},
  volume       = {29},
  year         = {2010},
}