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Shaping up a lineage-lessons from B lymphopoesis.

Bryder, David LU and Sigvardsson, Mikael LU (2010) In Current opinion in immunology Apr 7. p.148-153
Abstract
Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or B220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid... (More)
Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or B220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current opinion in immunology
volume
Apr 7
pages
148 - 153
external identifiers
  • WOS:000277811800002
  • PMID:20207528
  • Scopus:77951255407
ISSN
1879-0372
DOI
10.1016/j.coi.2010.02.001
language
English
LU publication?
yes
id
f8234616-e1fe-4c7a-a2f8-ed7586d34830 (old id 1582508)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20207528?dopt=Abstract
date added to LUP
2010-04-07 13:39:16
date last changed
2016-10-13 04:32:43
@misc{f8234616-e1fe-4c7a-a2f8-ed7586d34830,
  abstract     = {Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or B220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system.},
  author       = {Bryder, David and Sigvardsson, Mikael},
  issn         = {1879-0372},
  language     = {eng},
  pages        = {148--153},
  series       = {Current opinion in immunology},
  title        = {Shaping up a lineage-lessons from B lymphopoesis.},
  url          = {http://dx.doi.org/10.1016/j.coi.2010.02.001},
  volume       = {Apr 7},
  year         = {2010},
}