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Prevalence and incidence of rheumatoid arthritis in southern Sweden 2008 and their relation to prescribed biologics.

Englund, Martin LU ; Jöud, Anna; Geborek, Pierre LU ; Felson, David T; Jacobsson, Lennart LU and Petersson, Ingemar LU (2010) In Rheumatology (Oxford, England) 49. p.1563-1569
Abstract
Objectives. To gain updated estimates of prevalence and incidence of RA and proportion on biological treatment in southern Sweden. Methods. Inpatient and outpatient health care provided to residents in the southernmost county of Sweden (1.2 million inhabitants) is registered in the Skåne Health Care Register (SHCR). We identified residents aged >/=20 years who had received a diagnosis of RA at least twice during 2003-08. Valid point prevalence estimates by 31 December 2008 were obtained by linkage to the Swedish population register, and information on biological treatment was obtained from the South Swedish Arthritis Treatment Group register. We also tested our estimates of RA occurrence in a series of sensitivity analyses to... (More)
Objectives. To gain updated estimates of prevalence and incidence of RA and proportion on biological treatment in southern Sweden. Methods. Inpatient and outpatient health care provided to residents in the southernmost county of Sweden (1.2 million inhabitants) is registered in the Skåne Health Care Register (SHCR). We identified residents aged >/=20 years who had received a diagnosis of RA at least twice during 2003-08. Valid point prevalence estimates by 31 December 2008 were obtained by linkage to the Swedish population register, and information on biological treatment was obtained from the South Swedish Arthritis Treatment Group register. We also tested our estimates of RA occurrence in a series of sensitivity analyses to investigate the effect of altered case criteria and the uncertainty generated by clinical visits without diagnoses. Results. The prevalence of RA in adults was estimated to 0.66% (women = 0.94%, men = 0.37%). The prevalence peaked at age 70-79 years (women = 2.1%, men = 1.1%) before dropping in those aged >/=80 years. Of prevalent cases, 20% had ongoing biological treatment, a percentage that was highest in women aged 40-49 years (36%). The incidence of RA in 2008 was estimated as 50/100 000 (women = 68/100 000, men = 32/100 000). Conclusions. When compared with a previous report from southern Sweden, the prevalence of RA seems not to have declined in the last decade. The proportion of patients with ongoing biological treatment was slightly higher in women than men. SHCR data are promising additions to other methods to gain frequency estimates of clinically important disease in a timely and cost-efficient manner. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology (Oxford, England)
volume
49
pages
1563 - 1569
publisher
Oxford University Press
external identifiers
  • WOS:000280014300021
  • PMID:20444855
  • Scopus:77954711942
ISSN
1462-0332
DOI
10.1093/rheumatology/keq127
language
English
LU publication?
yes
id
5f803308-b1f5-4541-a059-4bfbd5e66e2e (old id 1610589)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20444855?dopt=Abstract
date added to LUP
2010-06-01 08:58:34
date last changed
2016-12-04 04:40:25
@misc{5f803308-b1f5-4541-a059-4bfbd5e66e2e,
  abstract     = {Objectives. To gain updated estimates of prevalence and incidence of RA and proportion on biological treatment in southern Sweden. Methods. Inpatient and outpatient health care provided to residents in the southernmost county of Sweden (1.2 million inhabitants) is registered in the Skåne Health Care Register (SHCR). We identified residents aged >/=20 years who had received a diagnosis of RA at least twice during 2003-08. Valid point prevalence estimates by 31 December 2008 were obtained by linkage to the Swedish population register, and information on biological treatment was obtained from the South Swedish Arthritis Treatment Group register. We also tested our estimates of RA occurrence in a series of sensitivity analyses to investigate the effect of altered case criteria and the uncertainty generated by clinical visits without diagnoses. Results. The prevalence of RA in adults was estimated to 0.66% (women = 0.94%, men = 0.37%). The prevalence peaked at age 70-79 years (women = 2.1%, men = 1.1%) before dropping in those aged >/=80 years. Of prevalent cases, 20% had ongoing biological treatment, a percentage that was highest in women aged 40-49 years (36%). The incidence of RA in 2008 was estimated as 50/100 000 (women = 68/100 000, men = 32/100 000). Conclusions. When compared with a previous report from southern Sweden, the prevalence of RA seems not to have declined in the last decade. The proportion of patients with ongoing biological treatment was slightly higher in women than men. SHCR data are promising additions to other methods to gain frequency estimates of clinically important disease in a timely and cost-efficient manner.},
  author       = {Englund, Martin and Jöud, Anna and Geborek, Pierre and Felson, David T and Jacobsson, Lennart and Petersson, Ingemar},
  issn         = {1462-0332},
  language     = {eng},
  pages        = {1563--1569},
  publisher    = {ARRAY(0xa2100a8)},
  series       = {Rheumatology (Oxford, England)},
  title        = {Prevalence and incidence of rheumatoid arthritis in southern Sweden 2008 and their relation to prescribed biologics.},
  url          = {http://dx.doi.org/10.1093/rheumatology/keq127},
  volume       = {49},
  year         = {2010},
}