Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.
Schmitt, Roland LU ; Lindahl, Gunnar LU and Karpman, Diana LU
(2010)
15th Congress of the International Pediatric Nephrology Association
In Pediatric Nephrology
25(9).
p.1830-1830
- Abstract
- BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs... (More)
- BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1625933
- author
- Schmitt, Roland
LU
; Lindahl, Gunnar
LU
and Karpman, Diana
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Nephrology
- volume
- 25
- issue
- 9
- article number
- 172
- pages
- 1830 - 1830
- publisher
- Springer
- conference name
- 15th Congress of the International Pediatric Nephrology Association
- conference location
- New York, NY, United States
- conference dates
- 2010-08-29 - 2010-09-02
- ISSN
- 1432-198X
- DOI
- 10.1007/s00467-010-1577-z
- language
- English
- LU publication?
- yes
- id
- 777d8268-5546-424f-ab00-087418886ab3 (old id 1625933)
- date added to LUP
- 2016-04-04 09:08:57
- date last changed
- 2021-08-11 04:00:11
@misc{777d8268-5546-424f-ab00-087418886ab3,
abstract = {{BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.}},
author = {{Schmitt, Roland and Lindahl, Gunnar and Karpman, Diana}},
issn = {{1432-198X}},
language = {{eng}},
note = {{Conference Abstract}},
number = {{9}},
pages = {{1830--1830}},
publisher = {{Springer}},
series = {{Pediatric Nephrology}},
title = {{Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.}},
url = {{https://lup.lub.lu.se/search/files/5245022/1660528.pdf}},
doi = {{10.1007/s00467-010-1577-z}},
volume = {{25}},
year = {{2010}},
}