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Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.

Schmitt, Roland LU ; Lindahl, Gunnar LU and Karpman, Diana LU (2010) In Pediatric Nephrology 25(9). p.1830-1830
Abstract
BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs... (More)
BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Nephrology
volume
25
issue
9
pages
1830 - 1830
publisher
Springer
external identifiers
  • WOS:000280247200201
  • PMID:20558662
  • Scopus:77957225927
ISSN
1432-198X
DOI
10.1093/ndt/gfq346
language
English
LU publication?
yes
id
777d8268-5546-424f-ab00-087418886ab3 (old id 1625933)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20558662?dopt=Abstract
date added to LUP
2010-07-05 20:49:29
date last changed
2016-10-13 04:24:51
@misc{777d8268-5546-424f-ab00-087418886ab3,
  abstract     = {BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.},
  author       = {Schmitt, Roland and Lindahl, Gunnar and Karpman, Diana},
  issn         = {1432-198X},
  language     = {eng},
  number       = {9},
  pages        = {1830--1830},
  publisher    = {ARRAY(0x8ce41f8)},
  series       = {Pediatric Nephrology},
  title        = {Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.},
  url          = {http://dx.doi.org/10.1093/ndt/gfq346},
  volume       = {25},
  year         = {2010},
}