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Mitochondrial ion circuits.

Nicholls, David LU (2010) In Essays in Biochemistry 47. p.25-35
Abstract
Proton circuits across the inner mitochondrial membrane link the primary energy generators, namely the complexes of the electron transport chain, to multiple energy utilizing processes, including the ATP synthase, inherent proton leak pathways, metabolite transport and linked circuits of sodium and calcium. These mitochondrial circuits can be monitored in both isolated preparations and intact cells and, for the primary proton circuit techniques, exist to follow both the proton current and proton electrochemical potential components of the circuit in parallel experiments, providing a quantitative means of assessing mitochondrial function and, equally importantly, dysfunction.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Essays in Biochemistry
volume
47
pages
25 - 35
publisher
Portland Press
external identifiers
  • WOS:000279550900002
  • PMID:20533898
  • Scopus:79951978630
ISSN
0071-1365
DOI
10.1042/bse0470025
language
English
LU publication?
yes
id
152271f5-cd80-4b6f-8e62-844a49d193ae (old id 1626239)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20533898?dopt=Abstract
date added to LUP
2010-07-05 09:59:42
date last changed
2016-10-13 04:26:35
@misc{152271f5-cd80-4b6f-8e62-844a49d193ae,
  abstract     = {Proton circuits across the inner mitochondrial membrane link the primary energy generators, namely the complexes of the electron transport chain, to multiple energy utilizing processes, including the ATP synthase, inherent proton leak pathways, metabolite transport and linked circuits of sodium and calcium. These mitochondrial circuits can be monitored in both isolated preparations and intact cells and, for the primary proton circuit techniques, exist to follow both the proton current and proton electrochemical potential components of the circuit in parallel experiments, providing a quantitative means of assessing mitochondrial function and, equally importantly, dysfunction.},
  author       = {Nicholls, David},
  issn         = {0071-1365},
  language     = {eng},
  pages        = {25--35},
  publisher    = {ARRAY(0x7c9e988)},
  series       = {Essays in Biochemistry},
  title        = {Mitochondrial ion circuits.},
  url          = {http://dx.doi.org/10.1042/bse0470025},
  volume       = {47},
  year         = {2010},
}