The role of calcium in neutrophil granule-phagosome fusion.
Nordenfelt, Pontus LU
and Tapper, Hans
LU
(2010)
In Communicative & Integrative Biology
3(3).
p.224-226
- Abstract
- During phagocytosis, neutrophils kill microorganisms by delivering antimicrobial substances to the phagosome. For this, the intracellular targeting and fusion of granules must be strictly regulated and a dependence on the cytosolic concentration of free calcium has been suggested. New evidence show that different mechanisms regulate early and late stages of Fc receptor-mediated phagocytosis. The early fusion events are dependent on calcium but this is not the case for the fusion of azurophilic granules with phagosomes at later stages. Certain pathogens target the granule-phagosome fusion machinery in order to survive intracellularly; a deeper understanding of intracellular membrane traffic processes could allow new approaches for the... (More)
- During phagocytosis, neutrophils kill microorganisms by delivering antimicrobial substances to the phagosome. For this, the intracellular targeting and fusion of granules must be strictly regulated and a dependence on the cytosolic concentration of free calcium has been suggested. New evidence show that different mechanisms regulate early and late stages of Fc receptor-mediated phagocytosis. The early fusion events are dependent on calcium but this is not the case for the fusion of azurophilic granules with phagosomes at later stages. Certain pathogens target the granule-phagosome fusion machinery in order to survive intracellularly; a deeper understanding of intracellular membrane traffic processes could allow new approaches for the eradication of pathogens that are harbored inside the cells of our immune system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1665242
- author
- Nordenfelt, Pontus
LU
and Tapper, Hans
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Communicative & Integrative Biology
- volume
- 3
- issue
- 3
- pages
- 224 - 226
- publisher
- Landes Bioscience
- external identifiers
-
- pmid:20714398
- scopus:80054979292
- ISSN
- 1942-0889
- language
- English
- LU publication?
- yes
- id
- 3ffbd4ff-fb90-473b-9aea-a5f7963bf0b7 (old id 1665242)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20714398?dopt=Abstract
- date added to LUP
- 2016-04-04 09:29:54
- date last changed
- 2022-01-29 18:10:55
@article{3ffbd4ff-fb90-473b-9aea-a5f7963bf0b7,
abstract = {{During phagocytosis, neutrophils kill microorganisms by delivering antimicrobial substances to the phagosome. For this, the intracellular targeting and fusion of granules must be strictly regulated and a dependence on the cytosolic concentration of free calcium has been suggested. New evidence show that different mechanisms regulate early and late stages of Fc receptor-mediated phagocytosis. The early fusion events are dependent on calcium but this is not the case for the fusion of azurophilic granules with phagosomes at later stages. Certain pathogens target the granule-phagosome fusion machinery in order to survive intracellularly; a deeper understanding of intracellular membrane traffic processes could allow new approaches for the eradication of pathogens that are harbored inside the cells of our immune system.}},
author = {{Nordenfelt, Pontus and Tapper, Hans}},
issn = {{1942-0889}},
language = {{eng}},
number = {{3}},
pages = {{224--226}},
publisher = {{Landes Bioscience}},
series = {{Communicative & Integrative Biology}},
title = {{The role of calcium in neutrophil granule-phagosome fusion.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/20714398?dopt=Abstract}},
volume = {{3}},
year = {{2010}},
}