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Ultrastructure of the epiphyseal plate of the guinea pig in experimental scurvy

Thyberg, J.; Lohmander, Stefan LU and Friberg, U. (1971) In Virchows Archiv B Cell Pathology Zell-pathologie 9(1). p.45-57
Abstract

The ultrastructure of the upper tibial epiphyseal plate during the development of acute, experimental scurvy in the guinea pig was investigated. The cartilage was examined after the animals had been maintained, under standardized conditions, on a scorbutogenic diet for 8, 15, or 23 days. Progressive fine structural changes were observed in the experimental animals. Within the chondrocytes, the cisternae of the endoplasmic reticulum were rounded, non-continuous, and reduced in extensiveness. There was a decreased number of ribosomes on the cisternal membranes and, concomitantly, an increased amount of free ribosomes in the ground cytoplasm. The secretory vacuoles of the Golgi complex were few. Lysosomes were more frequent than in the... (More)

The ultrastructure of the upper tibial epiphyseal plate during the development of acute, experimental scurvy in the guinea pig was investigated. The cartilage was examined after the animals had been maintained, under standardized conditions, on a scorbutogenic diet for 8, 15, or 23 days. Progressive fine structural changes were observed in the experimental animals. Within the chondrocytes, the cisternae of the endoplasmic reticulum were rounded, non-continuous, and reduced in extensiveness. There was a decreased number of ribosomes on the cisternal membranes and, concomitantly, an increased amount of free ribosomes in the ground cytoplasm. The secretory vacuoles of the Golgi complex were few. Lysosomes were more frequent than in the controls. Signs of autophagocytosis were often observed. In the ground cytoplasm lipid droplets occurred somewhat more often than in the control animals. In the intercellular substance the amount of collagen fibrils and proteoglycan particles was decreased. Electron-dense matrix vesicles were numerous in the longitudinal septa. The nature of these changes is discussed with regard to the biochemical alterations that have been observed in this disorder. © 1971 Springer-Verlag.

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organization
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type
Contribution to journal
publication status
published
in
Virchows Archiv B Cell Pathology Zell-pathologie
volume
9
issue
1
pages
13 pages
publisher
Springer Verlag
external identifiers
  • Scopus:0015004377
ISSN
0042-6431
DOI
10.1007/BF02894034
language
English
LU publication?
yes
id
16a3c9c1-c2ea-4291-80d3-645a5220b5d5
date added to LUP
2016-05-04 12:35:52
date last changed
2016-07-04 10:36:58
@misc{16a3c9c1-c2ea-4291-80d3-645a5220b5d5,
  abstract     = {<p>The ultrastructure of the upper tibial epiphyseal plate during the development of acute, experimental scurvy in the guinea pig was investigated. The cartilage was examined after the animals had been maintained, under standardized conditions, on a scorbutogenic diet for 8, 15, or 23 days. Progressive fine structural changes were observed in the experimental animals. Within the chondrocytes, the cisternae of the endoplasmic reticulum were rounded, non-continuous, and reduced in extensiveness. There was a decreased number of ribosomes on the cisternal membranes and, concomitantly, an increased amount of free ribosomes in the ground cytoplasm. The secretory vacuoles of the Golgi complex were few. Lysosomes were more frequent than in the controls. Signs of autophagocytosis were often observed. In the ground cytoplasm lipid droplets occurred somewhat more often than in the control animals. In the intercellular substance the amount of collagen fibrils and proteoglycan particles was decreased. Electron-dense matrix vesicles were numerous in the longitudinal septa. The nature of these changes is discussed with regard to the biochemical alterations that have been observed in this disorder. © 1971 Springer-Verlag.</p>},
  author       = {Thyberg, J. and Lohmander, Stefan and Friberg, U.},
  issn         = {0042-6431},
  language     = {eng},
  number       = {1},
  pages        = {45--57},
  publisher    = {ARRAY(0xb859fa8)},
  series       = {Virchows Archiv B Cell Pathology Zell-pathologie},
  title        = {Ultrastructure of the epiphyseal plate of the guinea pig in experimental scurvy},
  url          = {http://dx.doi.org/10.1007/BF02894034},
  volume       = {9},
  year         = {1971},
}