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Cytokine levels in the blood may distinguish suicide attempters from depressed patients.

Janelidze, Shorena LU ; Mattei, Daniele; Westrin, Åsa LU ; Träskman Bendz, Lil LU and Brundin, Lena LU (2011) In Brain, Behavior, and Immunity 25. p.335-339
Abstract
Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressive patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosis factor (TNF)-α were measured in 47 suicide attempters, 17 non-suicidal depressed patients and 16 healthy controls. Study participants were evaluated using the Comprehensive Psychopathological Rating Scale (CPRS) with subscales for anxiety and degree of depression, as well as the Suicide Assessment Scale (SUAS). We found increased levels of IL-6... (More)
Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressive patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosis factor (TNF)-α were measured in 47 suicide attempters, 17 non-suicidal depressed patients and 16 healthy controls. Study participants were evaluated using the Comprehensive Psychopathological Rating Scale (CPRS) with subscales for anxiety and degree of depression, as well as the Suicide Assessment Scale (SUAS). We found increased levels of IL-6 and TNF-α as well as decreased IL-2 concentrations in suicide attempters compared to non-suicidal depressed patients and healthy controls. The results were adjusted for potential confounders of cytokine expression, such as age, sex, body mass index (BMI), degree of depression, anxiety, personality disturbance, abuse and type of medication. These results demonstrate for the first time that suicidal patients display a distinct peripheral blood cytokine profile compared to non-suicidal depressed patients. Thus, our study provides further support for a role of inflammation in the pathophysiology of suicidality. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain, Behavior, and Immunity
volume
25
pages
335 - 339
publisher
Elsevier
external identifiers
  • WOS:000286699500017
  • PMID:20951793
  • Scopus:78651451984
ISSN
1090-2139
DOI
10.1016/j.bbi.2010.10.010
language
English
LU publication?
yes
id
e1271e2c-5624-40be-8c22-68277d02ab83 (old id 1711071)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20951793?dopt=Abstract
date added to LUP
2010-11-05 15:33:06
date last changed
2016-12-04 04:40:31
@misc{e1271e2c-5624-40be-8c22-68277d02ab83,
  abstract     = {Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressive patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosis factor (TNF)-α were measured in 47 suicide attempters, 17 non-suicidal depressed patients and 16 healthy controls. Study participants were evaluated using the Comprehensive Psychopathological Rating Scale (CPRS) with subscales for anxiety and degree of depression, as well as the Suicide Assessment Scale (SUAS). We found increased levels of IL-6 and TNF-α as well as decreased IL-2 concentrations in suicide attempters compared to non-suicidal depressed patients and healthy controls. The results were adjusted for potential confounders of cytokine expression, such as age, sex, body mass index (BMI), degree of depression, anxiety, personality disturbance, abuse and type of medication. These results demonstrate for the first time that suicidal patients display a distinct peripheral blood cytokine profile compared to non-suicidal depressed patients. Thus, our study provides further support for a role of inflammation in the pathophysiology of suicidality.},
  author       = {Janelidze, Shorena and Mattei, Daniele and Westrin, Åsa and Träskman Bendz, Lil and Brundin, Lena},
  issn         = {1090-2139},
  language     = {eng},
  pages        = {335--339},
  publisher    = {ARRAY(0xc3f90c8)},
  series       = {Brain, Behavior, and Immunity},
  title        = {Cytokine levels in the blood may distinguish suicide attempters from depressed patients.},
  url          = {http://dx.doi.org/10.1016/j.bbi.2010.10.010},
  volume       = {25},
  year         = {2011},
}