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Heart transplantation with ABO-identical versus ABO-compatible cardiac grafts: Influence on long-term survival.

Sjögren, Johan LU ; Ljungdahl, Fredrik; Senneby, Erik; Ekmehag, Björn LU ; Koul, Bansi LU and Nilsson, Johan LU (2010) In Scandinavian cardiovascular journal : SCJ 44(6). p.373-379
Abstract
Abstract Objectives. To compare identical versus compatible, ABO blood group matching effects on rejection and long-term survival after heart transplantation (HT). Design. Data were collected from 196 patients who underwent HT at Lund University Hospital between 1988 and 2008. Cox proportion hazard regression analysis was used to identify factors associated with reduced long-term survival. Results. One hundred and sixty six patients (85%) had an identical ABO blood group match and 30 patients (15%) had a compatible, ABO blood group match. Four non-pharmacological variables reducing overall survival were identified: recipient blood group AB, age >55 years, ischemic time, and year of transplantation. Two pharmacological variables improved... (More)
Abstract Objectives. To compare identical versus compatible, ABO blood group matching effects on rejection and long-term survival after heart transplantation (HT). Design. Data were collected from 196 patients who underwent HT at Lund University Hospital between 1988 and 2008. Cox proportion hazard regression analysis was used to identify factors associated with reduced long-term survival. Results. One hundred and sixty six patients (85%) had an identical ABO blood group match and 30 patients (15%) had a compatible, ABO blood group match. Four non-pharmacological variables reducing overall survival were identified: recipient blood group AB, age >55 years, ischemic time, and year of transplantation. Two pharmacological variables improved overall survival: glucocorticoids and cyclosporine. There was no significant difference in long-term survival between patients with identical blood groups compared to compatible ABO blood group matching. However, there was a trend towards graft failure as cause of death being more common in the compatible ABO group match compared identical blood group match (13% versus 5%, p=0.118). Conclusions. Six factors associated with overall survival were identified. One of these was related to blood group AB. No significant difference in survival following identical, versus compatible, ABO matching was demonstrated. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian cardiovascular journal : SCJ
volume
44
issue
6
pages
373 - 379
publisher
Taylor & Francis
external identifiers
  • WOS:000284316000010
  • PMID:21080866
  • Scopus:78649238700
ISSN
1651-2006
DOI
10.3109/14017431.2010.509450
language
English
LU publication?
yes
id
d53d223f-ef4e-413b-96a7-16ffe907c145 (old id 1731933)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21080866?dopt=Abstract
date added to LUP
2010-12-01 12:38:46
date last changed
2016-11-08 14:10:29
@misc{d53d223f-ef4e-413b-96a7-16ffe907c145,
  abstract     = {Abstract Objectives. To compare identical versus compatible, ABO blood group matching effects on rejection and long-term survival after heart transplantation (HT). Design. Data were collected from 196 patients who underwent HT at Lund University Hospital between 1988 and 2008. Cox proportion hazard regression analysis was used to identify factors associated with reduced long-term survival. Results. One hundred and sixty six patients (85%) had an identical ABO blood group match and 30 patients (15%) had a compatible, ABO blood group match. Four non-pharmacological variables reducing overall survival were identified: recipient blood group AB, age >55 years, ischemic time, and year of transplantation. Two pharmacological variables improved overall survival: glucocorticoids and cyclosporine. There was no significant difference in long-term survival between patients with identical blood groups compared to compatible ABO blood group matching. However, there was a trend towards graft failure as cause of death being more common in the compatible ABO group match compared identical blood group match (13% versus 5%, p=0.118). Conclusions. Six factors associated with overall survival were identified. One of these was related to blood group AB. No significant difference in survival following identical, versus compatible, ABO matching was demonstrated.},
  author       = {Sjögren, Johan and Ljungdahl, Fredrik and Senneby, Erik and Ekmehag, Björn and Koul, Bansi and Nilsson, Johan},
  issn         = {1651-2006},
  language     = {eng},
  number       = {6},
  pages        = {373--379},
  publisher    = {ARRAY(0xd039d48)},
  series       = {Scandinavian cardiovascular journal : SCJ},
  title        = {Heart transplantation with ABO-identical versus ABO-compatible cardiac grafts: Influence on long-term survival.},
  url          = {http://dx.doi.org/10.3109/14017431.2010.509450},
  volume       = {44},
  year         = {2010},
}