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CSF biomarkers in suicide attempters - a principal component analysis.

Lindqvist, Daniel LU ; Janelidze, Shorena LU ; Erhardt, S; Träskman Bendz, Lil LU ; Engström, Gunnar LU and Brundin, Lena LU (2011) In Acta Psychiatrica Scandinavica 124. p.52-61
Abstract
Lindqvist D, Janelidze S, Erhardt S, Träskman-Bendz L, Engström G, Brundin L. CSF biomarkers in suicide attempters - a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) biomarkers in suicide attempters and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol, chemokines, matrix metalloproteases and cytokines in the CSF of 124 drug-free suicide attempters. Patients were evaluated for suicidality and psychiatric symptoms using well-defined psychiatric rating scales and followed-up regarding... (More)
Lindqvist D, Janelidze S, Erhardt S, Träskman-Bendz L, Engström G, Brundin L. CSF biomarkers in suicide attempters - a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) biomarkers in suicide attempters and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol, chemokines, matrix metalloproteases and cytokines in the CSF of 124 drug-free suicide attempters. Patients were evaluated for suicidality and psychiatric symptoms using well-defined psychiatric rating scales and followed-up regarding future suicide. We used principal component analysis to identify factors among the biological substances. Results: Four factors were extracted from the 20 biomarkers, explaining 52.4% of the total variance. Factors 1 and 2 were characterized by high loadings of chemokines and cytokines respectively. They were both associated with severe depressive symptoms. Factor 2 was also associated with a high suicidal intent. Factor 4 was characterized by strong loadings of the monoamine metabolites 5-HIAA and HVA, as well as orexin and interleukin-6. High scores on this factor were found in patients who performed a violent suicide attempt and in patients who subsequently completed suicide. Conclusion: Our results suggest that specific combinations of CSF biomarkers may discriminate between types of suicidal behaviour and indicate increased risk for future suicide. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Psychiatrica Scandinavica
volume
124
pages
52 - 61
publisher
Wiley-Blackwell
external identifiers
  • WOS:000292149500007
  • PMID:21198458
  • Scopus:79958743342
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2010.01655.x
language
English
LU publication?
yes
id
6e54decf-5cd0-4d3f-8c76-d5c3852b986d (old id 1777899)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21198458?dopt=Abstract
date added to LUP
2011-02-01 10:37:06
date last changed
2016-12-04 04:38:36
@misc{6e54decf-5cd0-4d3f-8c76-d5c3852b986d,
  abstract     = {Lindqvist D, Janelidze S, Erhardt S, Träskman-Bendz L, Engström G, Brundin L. CSF biomarkers in suicide attempters - a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) biomarkers in suicide attempters and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol, chemokines, matrix metalloproteases and cytokines in the CSF of 124 drug-free suicide attempters. Patients were evaluated for suicidality and psychiatric symptoms using well-defined psychiatric rating scales and followed-up regarding future suicide. We used principal component analysis to identify factors among the biological substances. Results: Four factors were extracted from the 20 biomarkers, explaining 52.4% of the total variance. Factors 1 and 2 were characterized by high loadings of chemokines and cytokines respectively. They were both associated with severe depressive symptoms. Factor 2 was also associated with a high suicidal intent. Factor 4 was characterized by strong loadings of the monoamine metabolites 5-HIAA and HVA, as well as orexin and interleukin-6. High scores on this factor were found in patients who performed a violent suicide attempt and in patients who subsequently completed suicide. Conclusion: Our results suggest that specific combinations of CSF biomarkers may discriminate between types of suicidal behaviour and indicate increased risk for future suicide.},
  author       = {Lindqvist, Daniel and Janelidze, Shorena and Erhardt, S and Träskman Bendz, Lil and Engström, Gunnar and Brundin, Lena},
  issn         = {1600-0447},
  language     = {eng},
  pages        = {52--61},
  publisher    = {ARRAY(0x9878550)},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {CSF biomarkers in suicide attempters - a principal component analysis.},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2010.01655.x},
  volume       = {124},
  year         = {2011},
}