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Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation.

Grubb, Anders LU ; Björk, Jonas LU ; Nyman, Ulf LU ; Pollak, Joanna LU ; Bengzon, Johan LU ; Östner, Gustav LU and Lindström, Veronica LU (2011) In Scandinavian Journal of Clinical and Laboratory Investigation 71. p.145-149
Abstract
Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association between cystatin C level and inflammation stem from large cohort studies. The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery. Methods. Cystatin C, creatinine, and the inflammatory markers CRP, serum amyloid A (SAA), haptoglobin... (More)
Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association between cystatin C level and inflammation stem from large cohort studies. The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery. Methods. Cystatin C, creatinine, and the inflammatory markers CRP, serum amyloid A (SAA), haptoglobin and orosomucoid were measured in plasma samples from 35 patients the day before elective surgery and subsequently during seven consecutive days. Results. Twenty patients had CRP-levels below 1 mg/L before surgery and low levels of the additional inflammatory markers. Surgery caused marked inflammation with high peak values of CRP and SAA on the second day after the operation. The cystatin C level did not change significantly during the observation period and did not correlate significantly with the level of any of the four inflammatory markers. The creatinine level was significantly reduced on the first postoperative day but reached the preoperative level towards the end of the observation period. Conclusion. The inflammatory status of a patient does not influence the role of cystatin C as a marker of successful aging, nor of GFR. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
71
pages
145 - 149
publisher
Informa Healthcare
external identifiers
  • WOS:000288126400012
  • PMID:21198422
  • Scopus:79952428528
ISSN
1502-7686
DOI
10.3109/00365513.2010.546879
language
English
LU publication?
yes
id
d3e8db72-b251-4062-a87b-0ed599084aba (old id 1777908)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21198422?dopt=Abstract
date added to LUP
2011-02-01 10:40:32
date last changed
2016-10-28 15:21:18
@misc{d3e8db72-b251-4062-a87b-0ed599084aba,
  abstract     = {Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association between cystatin C level and inflammation stem from large cohort studies. The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery. Methods. Cystatin C, creatinine, and the inflammatory markers CRP, serum amyloid A (SAA), haptoglobin and orosomucoid were measured in plasma samples from 35 patients the day before elective surgery and subsequently during seven consecutive days. Results. Twenty patients had CRP-levels below 1 mg/L before surgery and low levels of the additional inflammatory markers. Surgery caused marked inflammation with high peak values of CRP and SAA on the second day after the operation. The cystatin C level did not change significantly during the observation period and did not correlate significantly with the level of any of the four inflammatory markers. The creatinine level was significantly reduced on the first postoperative day but reached the preoperative level towards the end of the observation period. Conclusion. The inflammatory status of a patient does not influence the role of cystatin C as a marker of successful aging, nor of GFR.},
  author       = {Grubb, Anders and Björk, Jonas and Nyman, Ulf and Pollak, Joanna and Bengzon, Johan and Östner, Gustav and Lindström, Veronica},
  issn         = {1502-7686},
  language     = {eng},
  pages        = {145--149},
  publisher    = {ARRAY(0x9e20928)},
  series       = {Scandinavian Journal of Clinical and Laboratory Investigation},
  title        = {Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation.},
  url          = {http://dx.doi.org/10.3109/00365513.2010.546879},
  volume       = {71},
  year         = {2011},
}