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Substance P and vasoactive intestinal peptide influence polyamine metabolism in salivary glands of the rat

Nilsson, B O LU (1989) In Acta Physiol.Scand 136(3). p.33-427
Abstract

In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of the neuropeptides substance P or vasoactive intestinal peptide at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activity of ornithine decarboxylase were determined. This enzyme catalyses the synthesis of putrescine and is the key enzyme in polyamine formation. Vasoactive intestinal peptide induced the most marked effects, and the most conspicuous findings were made in the sublingual glands, where the ornithine decarboxylase activity was found to have increased more than 100-fold, accompanied by an increased level of putrescine in those glands which were... (More)

In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of the neuropeptides substance P or vasoactive intestinal peptide at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activity of ornithine decarboxylase were determined. This enzyme catalyses the synthesis of putrescine and is the key enzyme in polyamine formation. Vasoactive intestinal peptide induced the most marked effects, and the most conspicuous findings were made in the sublingual glands, where the ornithine decarboxylase activity was found to have increased more than 100-fold, accompanied by an increased level of putrescine in those glands which were removed immediately after the end of the infusion. When, instead, the glands were removed 5 h after the end of the infusion there was no longer any increase in the activity of ornithine decarboxylase or in putrescine concentration, but now spermidine and spermine were found to be increased. Interestingly, the parasympathetic non-adrenergic, non-cholinergic regulation of polyamine metabolism in the major salivary glands of the rat is most predominant in the sublingual glands.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Animals, Bethanechol, Bethanechol Compounds, Infusions, Intravenous, Male, Ornithine Decarboxylase, Polyamines, Putrescine, Rats, Rats, Inbred Strains, Salivary Glands, Spermidine, Spermine, Substance P, Vasoactive Intestinal Peptide
in
Acta Physiol.Scand
volume
136
issue
3
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0024402792
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1989.tb08684.x
language
English
LU publication?
yes
id
1785b09f-2c92-4668-b671-dd176ff62d16
date added to LUP
2016-06-17 16:49:22
date last changed
2016-07-04 12:39:40
@misc{1785b09f-2c92-4668-b671-dd176ff62d16,
  abstract     = {<p>In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of the neuropeptides substance P or vasoactive intestinal peptide at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activity of ornithine decarboxylase were determined. This enzyme catalyses the synthesis of putrescine and is the key enzyme in polyamine formation. Vasoactive intestinal peptide induced the most marked effects, and the most conspicuous findings were made in the sublingual glands, where the ornithine decarboxylase activity was found to have increased more than 100-fold, accompanied by an increased level of putrescine in those glands which were removed immediately after the end of the infusion. When, instead, the glands were removed 5 h after the end of the infusion there was no longer any increase in the activity of ornithine decarboxylase or in putrescine concentration, but now spermidine and spermine were found to be increased. Interestingly, the parasympathetic non-adrenergic, non-cholinergic regulation of polyamine metabolism in the major salivary glands of the rat is most predominant in the sublingual glands.</p>},
  author       = {Nilsson, B O},
  issn         = {0001-6772},
  keyword      = {Animals,Bethanechol,Bethanechol Compounds,Infusions, Intravenous,Male,Ornithine Decarboxylase,Polyamines,Putrescine,Rats,Rats, Inbred Strains,Salivary Glands,Spermidine,Spermine,Substance P,Vasoactive Intestinal Peptide},
  language     = {eng},
  number       = {3},
  pages        = {33--427},
  publisher    = {ARRAY(0x88b2778)},
  series       = {Acta Physiol.Scand},
  title        = {Substance P and vasoactive intestinal peptide influence polyamine metabolism in salivary glands of the rat},
  url          = {http://dx.doi.org/10.1111/j.1748-1716.1989.tb08684.x},
  volume       = {136},
  year         = {1989},
}