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Early human pregnancy serum cytokine levels predict autoimmunity in offspring.

Lindehammer, Sabina LU ; Björck, Sara LU ; Lynch, Kristian LU ; Brundin, Charlotte LU ; Marsal, Karel LU ; Agardh, Daniel LU and Fex, Malin LU (2011) In Autoimmunity 44. p.445-452
Abstract
It is generally believed that pregnancy is mediated by a Th2 response, which includes cytokines that promote placental growth and are involved in inducing tolerance to the foetus. If the balance between Th1/and Th2-mediated cytokines is disrupted, systemic and local changes could predispose the foetus to future disease. Therefore, a shift in the Th1/Th2 balance during pregnancy, possibly caused by underlying environmental factors, could be associated with post-partum autoimmune disease in the offspring. Based on this presumption, we used celiac disease as a model to investigate whether autoimmunity is triggered in the foetus during early pregnancy, observed as changes in the mother's cytokine profile. Ten cytokines were measured by... (More)
It is generally believed that pregnancy is mediated by a Th2 response, which includes cytokines that promote placental growth and are involved in inducing tolerance to the foetus. If the balance between Th1/and Th2-mediated cytokines is disrupted, systemic and local changes could predispose the foetus to future disease. Therefore, a shift in the Th1/Th2 balance during pregnancy, possibly caused by underlying environmental factors, could be associated with post-partum autoimmune disease in the offspring. Based on this presumption, we used celiac disease as a model to investigate whether autoimmunity is triggered in the foetus during early pregnancy, observed as changes in the mother's cytokine profile. Ten cytokines were measured by electro-chemi-luminescent multiplex ELISA in serum samples obtained from mothers during early pregnancy. Cases included women with children who had developed verified celiac disease before the age of 5, who were compared with other women as matched controls. We observed that 7 out of 10 cytokine levels were significantly increased in our case mothers when compared to controls. Five of these belonged to what is generally known as a Th1-mediated response (TNF?, IFN?, IL-2, IL-1? and IL-12) and two were Th2 cytokines (IL-13 and IL-10). However, the IL-10 cytokine is known to have features from both arms of the immune system. These results were confirmed in a logistic regression model where five out of the initial seven cytokines remained. This study suggests that increase in Th1 serum cytokines may be associated with celiac disease in offspring. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Autoimmunity
volume
44
pages
445 - 452
publisher
Taylor & Francis
external identifiers
  • WOS:000293391900001
  • PMID:21306187
  • Scopus:80051527104
ISSN
0891-6934
DOI
10.3109/08916934.2010.549530
language
English
LU publication?
yes
id
8a60e44f-bb63-4445-a35d-28ef97d1376b (old id 1832082)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21306187?dopt=Abstract
date added to LUP
2011-03-01 13:51:21
date last changed
2016-10-30 04:35:05
@misc{8a60e44f-bb63-4445-a35d-28ef97d1376b,
  abstract     = {It is generally believed that pregnancy is mediated by a Th2 response, which includes cytokines that promote placental growth and are involved in inducing tolerance to the foetus. If the balance between Th1/and Th2-mediated cytokines is disrupted, systemic and local changes could predispose the foetus to future disease. Therefore, a shift in the Th1/Th2 balance during pregnancy, possibly caused by underlying environmental factors, could be associated with post-partum autoimmune disease in the offspring. Based on this presumption, we used celiac disease as a model to investigate whether autoimmunity is triggered in the foetus during early pregnancy, observed as changes in the mother's cytokine profile. Ten cytokines were measured by electro-chemi-luminescent multiplex ELISA in serum samples obtained from mothers during early pregnancy. Cases included women with children who had developed verified celiac disease before the age of 5, who were compared with other women as matched controls. We observed that 7 out of 10 cytokine levels were significantly increased in our case mothers when compared to controls. Five of these belonged to what is generally known as a Th1-mediated response (TNF?, IFN?, IL-2, IL-1? and IL-12) and two were Th2 cytokines (IL-13 and IL-10). However, the IL-10 cytokine is known to have features from both arms of the immune system. These results were confirmed in a logistic regression model where five out of the initial seven cytokines remained. This study suggests that increase in Th1 serum cytokines may be associated with celiac disease in offspring.},
  author       = {Lindehammer, Sabina and Björck, Sara and Lynch, Kristian and Brundin, Charlotte and Marsal, Karel and Agardh, Daniel and Fex, Malin},
  issn         = {0891-6934},
  language     = {eng},
  pages        = {445--452},
  publisher    = {ARRAY(0x92e0648)},
  series       = {Autoimmunity},
  title        = {Early human pregnancy serum cytokine levels predict autoimmunity in offspring.},
  url          = {http://dx.doi.org/10.3109/08916934.2010.549530},
  volume       = {44},
  year         = {2011},
}