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Food patterns, inflammation markers and incidence of cardiovascular disease: the Malmö Diet and Cancer study.

Hlebowicz, Joanna LU ; Persson, Margaretha LU ; Gullberg, Bo LU ; Sonestedt, Emily LU ; Wallström, Peter LU ; Drake, Isabel LU ; Nilsson, Jan LU ; Hedblad, Bo LU and Wirfält, Elisabet LU (2011) In Journal of Internal Medicine 270. p.365-376
Abstract
Objectives: To examine the associations between food patterns constructed using cluster analysis and markers of systemic and vascular inflammation, and incident cardiovascular disease (CVD) after 13 years of follow-up. Design: Population-based, prospective cohort study. Setting and subjects: Cluster analysis identified six food patterns from 43 food group variables among 4999 subjects, aged 45-68 years, who participated in the Malmö Diet and Cancer cardiovascular programme between 1991 and 1994. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2) ), C-reactive protein concentration and white blood cell (WBC) count were measured using blood samples at baseline. Incidence of CVD (coronary events and ischaemic stroke) was monitored over 13... (More)
Objectives: To examine the associations between food patterns constructed using cluster analysis and markers of systemic and vascular inflammation, and incident cardiovascular disease (CVD) after 13 years of follow-up. Design: Population-based, prospective cohort study. Setting and subjects: Cluster analysis identified six food patterns from 43 food group variables among 4999 subjects, aged 45-68 years, who participated in the Malmö Diet and Cancer cardiovascular programme between 1991 and 1994. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2) ), C-reactive protein concentration and white blood cell (WBC) count were measured using blood samples at baseline. Incidence of CVD (coronary events and ischaemic stroke) was monitored over 13 years of follow-up. Results: The fibre-rich bread pattern was associated with favourable effects on WBC count in women, and the low-fat and high-fibre pattern with favourable effects on Lp-PLA(2) mass in women, and on Lp-PLA(2) activity in men. However, the milk fat and sweets and cakes patterns were both associated with adverse effects; the former on WBC count in women and on Lp-PLA(2) mass in men, and the latter on WBC count and Lp-PLA(2) mass in women. The milk fat and sweets and cakes patterns were associated with increased CVD risk in women. Conclusions: The results of this study support the present Nordic dietary recommendations indicating that diets rich in high-fibre, low-fat and low-sugar foods are favourably associated with markers of inflammation and, potentially, with CVD risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
270
pages
365 - 376
publisher
Wiley-Blackwell
external identifiers
  • WOS:000295096600010
  • PMID:21443679
  • Scopus:80052970259
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2011.02382.x
language
English
LU publication?
yes
id
aafbf1bd-3245-482a-ae7b-274dfc03ca33 (old id 1883383)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21443679?dopt=Abstract
date added to LUP
2011-04-01 22:20:19
date last changed
2016-10-13 04:32:41
@misc{aafbf1bd-3245-482a-ae7b-274dfc03ca33,
  abstract     = {Objectives: To examine the associations between food patterns constructed using cluster analysis and markers of systemic and vascular inflammation, and incident cardiovascular disease (CVD) after 13 years of follow-up. Design: Population-based, prospective cohort study. Setting and subjects: Cluster analysis identified six food patterns from 43 food group variables among 4999 subjects, aged 45-68 years, who participated in the Malmö Diet and Cancer cardiovascular programme between 1991 and 1994. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2) ), C-reactive protein concentration and white blood cell (WBC) count were measured using blood samples at baseline. Incidence of CVD (coronary events and ischaemic stroke) was monitored over 13 years of follow-up. Results: The fibre-rich bread pattern was associated with favourable effects on WBC count in women, and the low-fat and high-fibre pattern with favourable effects on Lp-PLA(2) mass in women, and on Lp-PLA(2) activity in men. However, the milk fat and sweets and cakes patterns were both associated with adverse effects; the former on WBC count in women and on Lp-PLA(2) mass in men, and the latter on WBC count and Lp-PLA(2) mass in women. The milk fat and sweets and cakes patterns were associated with increased CVD risk in women. Conclusions: The results of this study support the present Nordic dietary recommendations indicating that diets rich in high-fibre, low-fat and low-sugar foods are favourably associated with markers of inflammation and, potentially, with CVD risk.},
  author       = {Hlebowicz, Joanna and Persson, Margaretha and Gullberg, Bo and Sonestedt, Emily and Wallström, Peter and Drake, Isabel and Nilsson, Jan and Hedblad, Bo and Wirfält, Elisabet},
  issn         = {1365-2796},
  language     = {eng},
  pages        = {365--376},
  publisher    = {ARRAY(0x97c73d8)},
  series       = {Journal of Internal Medicine},
  title        = {Food patterns, inflammation markers and incidence of cardiovascular disease: the Malmö Diet and Cancer study.},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2011.02382.x},
  volume       = {270},
  year         = {2011},
}