Coronary microembolization causes long-term detrimental effects on regional left ventricular function.
(2011) In Scandinavian cardiovascular journal : SCJ 45. p.205-214- Abstract
- Abstract Objectives. To investigate whether coronary microemboli have long-term effects on left ventricular (LV) function in an experimental model. Furthermore, to determine if first-pass perfusion and late gadolinium enhancement (LGE) patterns differs between small- and large-sized microemboli. Design. Six pigs underwent left anterior descending (LAD)-coronary microembolization with small-sized (40-120 μm, n∼250 000) microemboli using a combined x-ray and MRI-system. MR-images before, one hour after and 7-8 weeks after microembolization were obtained. Results were compared to MRI obtained by large-sized (100-300 μm, n∼7200) microemboli. Results. Cine MRI showed an acute drop in ejection fraction (from 49.5 ± 2.6% to 32.5 ± 2.8) that... (More)
- Abstract Objectives. To investigate whether coronary microemboli have long-term effects on left ventricular (LV) function in an experimental model. Furthermore, to determine if first-pass perfusion and late gadolinium enhancement (LGE) patterns differs between small- and large-sized microemboli. Design. Six pigs underwent left anterior descending (LAD)-coronary microembolization with small-sized (40-120 μm, n∼250 000) microemboli using a combined x-ray and MRI-system. MR-images before, one hour after and 7-8 weeks after microembolization were obtained. Results were compared to MRI obtained by large-sized (100-300 μm, n∼7200) microemboli. Results. Cine MRI showed an acute drop in ejection fraction (from 49.5 ± 2.6% to 32.5 ± 2.8) that substantially recovered at 7-8 weeks (47.5 ± 3.2%). Regional LV-function assessed as circumferential, longitudinal and radial strain declined in both microinfarcts and remote regions followed by partial recovery at 7-8 weeks. The decline in LV function and the severe perfusion deficit from the small microemboli was similar to the large microemboli at one hour. There was a significant recovery in perfusion at 7-8 weeks in the microinfarcts. LGE demonstrated the microinfarcts at 7-8 weeks but not at one hour and the microinfarcts were confirmed by histopathology. Conclusion. Microembolization causes long-term, regional LV dysfunction and this study confirmed the need of a comprehensive MRI-protocol for the detection of microinfarcts. These findings suggest that even small microemboli (40-120 μm in diameter), which may escape the distal protective devices influence cardiac function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1937529
- author
- Carlsson, Marcus LU ; Jablonowski, Robert ; Martin, Alastair J ; Ursell, Philip C and Saeed, Maythem
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian cardiovascular journal : SCJ
- volume
- 45
- pages
- 205 - 214
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000292919500003
- pmid:21463182
- scopus:79960726360
- ISSN
- 1651-2006
- DOI
- 10.3109/14017431.2011.568629
- language
- English
- LU publication?
- yes
- id
- 61abd6df-ec33-4fbe-98b4-99b55271ac35 (old id 1937529)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21463182?dopt=Abstract
- date added to LUP
- 2016-04-04 09:23:59
- date last changed
- 2022-04-08 02:53:22
@article{61abd6df-ec33-4fbe-98b4-99b55271ac35,
abstract = {{Abstract Objectives. To investigate whether coronary microemboli have long-term effects on left ventricular (LV) function in an experimental model. Furthermore, to determine if first-pass perfusion and late gadolinium enhancement (LGE) patterns differs between small- and large-sized microemboli. Design. Six pigs underwent left anterior descending (LAD)-coronary microembolization with small-sized (40-120 μm, n∼250 000) microemboli using a combined x-ray and MRI-system. MR-images before, one hour after and 7-8 weeks after microembolization were obtained. Results were compared to MRI obtained by large-sized (100-300 μm, n∼7200) microemboli. Results. Cine MRI showed an acute drop in ejection fraction (from 49.5 ± 2.6% to 32.5 ± 2.8) that substantially recovered at 7-8 weeks (47.5 ± 3.2%). Regional LV-function assessed as circumferential, longitudinal and radial strain declined in both microinfarcts and remote regions followed by partial recovery at 7-8 weeks. The decline in LV function and the severe perfusion deficit from the small microemboli was similar to the large microemboli at one hour. There was a significant recovery in perfusion at 7-8 weeks in the microinfarcts. LGE demonstrated the microinfarcts at 7-8 weeks but not at one hour and the microinfarcts were confirmed by histopathology. Conclusion. Microembolization causes long-term, regional LV dysfunction and this study confirmed the need of a comprehensive MRI-protocol for the detection of microinfarcts. These findings suggest that even small microemboli (40-120 μm in diameter), which may escape the distal protective devices influence cardiac function.}},
author = {{Carlsson, Marcus and Jablonowski, Robert and Martin, Alastair J and Ursell, Philip C and Saeed, Maythem}},
issn = {{1651-2006}},
language = {{eng}},
pages = {{205--214}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian cardiovascular journal : SCJ}},
title = {{Coronary microembolization causes long-term detrimental effects on regional left ventricular function.}},
url = {{http://dx.doi.org/10.3109/14017431.2011.568629}},
doi = {{10.3109/14017431.2011.568629}},
volume = {{45}},
year = {{2011}},
}