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Tumour markers in prostate cancer II: diagnostic and prognostic cellular biomarkers.

Bjartell, Anders LU ; Montironi, Rodolfo; Berney, Daniel M and Egevad, Lars (2011) In Acta oncologica (Stockholm, Sweden) 50 Suppl 1. p.76-84
Abstract
The main goal of prostate cancer tissue biomarkers is to improve diagnostic and prognostic accuracy. A particularly important question is whether the cancer needs immediate treatment or if treatment can be deferred. It is highly unlikely that a single biomarker that provides comprehensive prognostic information about a newly diagnosed prostate cancer will be forthcoming. Despite extensive research efforts, very few biomarkers of prostate cancer have been successfully implemented into clinical practice today. This can be partly explained by a lack of standardised methods for performance and interpretation of immunohistochemistry, but also by poor study design with insufficient biomaterial or inappropriate statistical analysis. Also... (More)
The main goal of prostate cancer tissue biomarkers is to improve diagnostic and prognostic accuracy. A particularly important question is whether the cancer needs immediate treatment or if treatment can be deferred. It is highly unlikely that a single biomarker that provides comprehensive prognostic information about a newly diagnosed prostate cancer will be forthcoming. Despite extensive research efforts, very few biomarkers of prostate cancer have been successfully implemented into clinical practice today. This can be partly explained by a lack of standardised methods for performance and interpretation of immunohistochemistry, but also by poor study design with insufficient biomaterial or inappropriate statistical analysis. Also appropriate cohorts to test prostate cancer biomarkers do not exist. It must be kept in mind that unsuccessful integration of new biomarkers in nomograms can also be explained by the good performance of the clinical and pathological base model with serum PSA as the only independent biomarker. A new biomarker must be powerful enough to improve this prediction model and not merely replace. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta oncologica (Stockholm, Sweden)
volume
50 Suppl 1
pages
76 - 84
publisher
Taylor & Francis
external identifiers
  • WOS:000290871000013
  • PMID:21604944
  • Scopus:79957456529
ISSN
1651-226X
DOI
10.3109/0284186X.2010.531284
language
English
LU publication?
yes
id
5695d6e4-6c81-45ce-a507-674cf217b474 (old id 1972190)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21604944?dopt=Abstract
date added to LUP
2011-06-07 22:22:42
date last changed
2016-10-13 04:26:19
@misc{5695d6e4-6c81-45ce-a507-674cf217b474,
  abstract     = {The main goal of prostate cancer tissue biomarkers is to improve diagnostic and prognostic accuracy. A particularly important question is whether the cancer needs immediate treatment or if treatment can be deferred. It is highly unlikely that a single biomarker that provides comprehensive prognostic information about a newly diagnosed prostate cancer will be forthcoming. Despite extensive research efforts, very few biomarkers of prostate cancer have been successfully implemented into clinical practice today. This can be partly explained by a lack of standardised methods for performance and interpretation of immunohistochemistry, but also by poor study design with insufficient biomaterial or inappropriate statistical analysis. Also appropriate cohorts to test prostate cancer biomarkers do not exist. It must be kept in mind that unsuccessful integration of new biomarkers in nomograms can also be explained by the good performance of the clinical and pathological base model with serum PSA as the only independent biomarker. A new biomarker must be powerful enough to improve this prediction model and not merely replace.},
  author       = {Bjartell, Anders and Montironi, Rodolfo and Berney, Daniel M and Egevad, Lars},
  issn         = {1651-226X},
  language     = {eng},
  pages        = {76--84},
  publisher    = {ARRAY(0x84c4bc0)},
  series       = {Acta oncologica (Stockholm, Sweden)},
  title        = {Tumour markers in prostate cancer II: diagnostic and prognostic cellular biomarkers.},
  url          = {http://dx.doi.org/10.3109/0284186X.2010.531284},
  volume       = {50 Suppl 1},
  year         = {2011},
}