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Pregnancy and fetal outcome in women with primary Sjogren's syndrome compared with women in the general population: a nested case-control study.

Hussein, Sarwen Z; Jacobsson, Lennart LU ; Lindquist, Pelle G and Theander, Elke LU (2011) In Rheumatology (Oxford, England) 50. p.1612-1617
Abstract
Objective. To study pregnancy and fetal outcome in women with primary SS (pSS) compared with women in the general population. Methods. In a nested case-control setting, variables related to pregnancy and fetal outcomes were compared. Cases (n = 16) were identified through registry linkage (Malmö pSS registry and a database entailing information of all pregnancies and deliveries in Malmö from 1990 through 2006). For each pregnancy with pSS, the following five deliveries from the same registry were chosen as controls (n = 80). Results. All cases fulfilled the American European Consensus Criteria for pSS and were positive for ANA and anti-SSA antibodies. Date of diagnosis was before pregnancy in 10 women and after delivery in 6. Mean age at... (More)
Objective. To study pregnancy and fetal outcome in women with primary SS (pSS) compared with women in the general population. Methods. In a nested case-control setting, variables related to pregnancy and fetal outcomes were compared. Cases (n = 16) were identified through registry linkage (Malmö pSS registry and a database entailing information of all pregnancies and deliveries in Malmö from 1990 through 2006). For each pregnancy with pSS, the following five deliveries from the same registry were chosen as controls (n = 80). Results. All cases fulfilled the American European Consensus Criteria for pSS and were positive for ANA and anti-SSA antibodies. Date of diagnosis was before pregnancy in 10 women and after delivery in 6. Mean age at delivery was significantly higher in women with pSS (33.6 years) vs controls (29.8 years). While pregnancy duration did not differ, mean birthweight was significantly lower in offspring of pSS mothers (3010 g) vs babies of control mothers (3458 g). Normal partus in contrast to vacuum extraction or Caesarean section was significantly more frequent in healthy women than in pSS women (83 vs 56%). Other pregnancy outcomes such as parity, miscarriages and Apgar score did not differ. There were no significant differences between women with a pSS diagnosis before or after the index pregnancy. Only one of the included pregnancies was complicated by intrauterine AV block. Conclusion. Pregnancy occurs later in life in pSS women. Mothers with pSS give birth to offspring with lower birthweight and less commonly have normal partus. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology (Oxford, England)
volume
50
pages
1612 - 1617
publisher
Oxford University Press
external identifiers
  • WOS:000294068500013
  • PMID:21531959
  • Scopus:80051946419
ISSN
1462-0332
DOI
10.1093/rheumatology/ker077
language
English
LU publication?
yes
id
38e8fe2c-997e-4549-a73d-5c07c843288d (old id 1973319)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21531959?dopt=Abstract
date added to LUP
2011-06-07 09:44:01
date last changed
2016-11-06 04:25:51
@misc{38e8fe2c-997e-4549-a73d-5c07c843288d,
  abstract     = {Objective. To study pregnancy and fetal outcome in women with primary SS (pSS) compared with women in the general population. Methods. In a nested case-control setting, variables related to pregnancy and fetal outcomes were compared. Cases (n = 16) were identified through registry linkage (Malmö pSS registry and a database entailing information of all pregnancies and deliveries in Malmö from 1990 through 2006). For each pregnancy with pSS, the following five deliveries from the same registry were chosen as controls (n = 80). Results. All cases fulfilled the American European Consensus Criteria for pSS and were positive for ANA and anti-SSA antibodies. Date of diagnosis was before pregnancy in 10 women and after delivery in 6. Mean age at delivery was significantly higher in women with pSS (33.6 years) vs controls (29.8 years). While pregnancy duration did not differ, mean birthweight was significantly lower in offspring of pSS mothers (3010 g) vs babies of control mothers (3458 g). Normal partus in contrast to vacuum extraction or Caesarean section was significantly more frequent in healthy women than in pSS women (83 vs 56%). Other pregnancy outcomes such as parity, miscarriages and Apgar score did not differ. There were no significant differences between women with a pSS diagnosis before or after the index pregnancy. Only one of the included pregnancies was complicated by intrauterine AV block. Conclusion. Pregnancy occurs later in life in pSS women. Mothers with pSS give birth to offspring with lower birthweight and less commonly have normal partus.},
  author       = {Hussein, Sarwen Z and Jacobsson, Lennart and Lindquist, Pelle G and Theander, Elke},
  issn         = {1462-0332},
  language     = {eng},
  pages        = {1612--1617},
  publisher    = {ARRAY(0x9b8a870)},
  series       = {Rheumatology (Oxford, England)},
  title        = {Pregnancy and fetal outcome in women with primary Sjogren's syndrome compared with women in the general population: a nested case-control study.},
  url          = {http://dx.doi.org/10.1093/rheumatology/ker077},
  volume       = {50},
  year         = {2011},
}