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Markers of cartilage metabolism in arthrosis

Lohmander, Stefan LU (1991) In Acta Orthopaedica 62(6). p.623-632
Abstract

The mechanisms involved in the disease process in arthrosis are largely unknown, with genetics, joint malalignment, overload or trauma, obesity, and aging as some of the known or suspected contributing factors. Even less well known is how these general factors are translated into disease mechanisms at the cell and tissue levels. However, it may be argued that degradation of cartilage matrix is a key event at some time in the development of arthrosis. During this process, fragments of matrix molecules and other chondrocyte products are released into the joint fluid and eventually into other body fluids. These molecules can be used as markers of cartilage metabolism to monitor joint disease. In addition, by identifying the proteases and... (More)

The mechanisms involved in the disease process in arthrosis are largely unknown, with genetics, joint malalignment, overload or trauma, obesity, and aging as some of the known or suspected contributing factors. Even less well known is how these general factors are translated into disease mechanisms at the cell and tissue levels. However, it may be argued that degradation of cartilage matrix is a key event at some time in the development of arthrosis. During this process, fragments of matrix molecules and other chondrocyte products are released into the joint fluid and eventually into other body fluids. These molecules can be used as markers of cartilage metabolism to monitor joint disease. In addition, by identifying the proteases and the structure of the released matrix fragments, we may improve our understanding of the cellular mechanisms active in cartilage degradation. Such information offers improved diagnostic and prognostic tools for rational treatment aimed at retarding cartilage destruction in arthrosis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glycosaminoglycan, polysulfate, nonsteroid antiinflammatory agent, knee injury
in
Acta Orthopaedica
volume
62
issue
6
pages
10 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:0026409292
ISSN
1745-3674
DOI
10.3109/17453679108994513
language
English
LU publication?
yes
id
1c454e01-29af-4ab0-969c-23f324124f75
date added to LUP
2016-05-04 18:21:09
date last changed
2016-12-04 04:51:10
@misc{1c454e01-29af-4ab0-969c-23f324124f75,
  abstract     = {<p>The mechanisms involved in the disease process in arthrosis are largely unknown, with genetics, joint malalignment, overload or trauma, obesity, and aging as some of the known or suspected contributing factors. Even less well known is how these general factors are translated into disease mechanisms at the cell and tissue levels. However, it may be argued that degradation of cartilage matrix is a key event at some time in the development of arthrosis. During this process, fragments of matrix molecules and other chondrocyte products are released into the joint fluid and eventually into other body fluids. These molecules can be used as markers of cartilage metabolism to monitor joint disease. In addition, by identifying the proteases and the structure of the released matrix fragments, we may improve our understanding of the cellular mechanisms active in cartilage degradation. Such information offers improved diagnostic and prognostic tools for rational treatment aimed at retarding cartilage destruction in arthrosis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.</p>},
  author       = {Lohmander, Stefan},
  issn         = {1745-3674},
  keyword      = {glycosaminoglycan,polysulfate,nonsteroid antiinflammatory agent,knee injury},
  language     = {eng},
  number       = {6},
  pages        = {623--632},
  publisher    = {ARRAY(0x99ad0d0)},
  series       = {Acta Orthopaedica},
  title        = {Markers of cartilage metabolism in arthrosis},
  url          = {http://dx.doi.org/10.3109/17453679108994513},
  volume       = {62},
  year         = {1991},
}