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Biological effects of aminoguanidine : an update

Nilsson, B O LU (1999) In Inflammation Research 48(10). p.15-509
Abstract

Aminoguanidine (AMG) was prepared more than 100 years ago. During the last 10 years two important effects of AMG have been discovered which have made this molecule attract a lot of interest. Firstly, AMG inhibits, in vitro and in vivo, formation of highly reactive advanced glycosylation end products (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. AMG ameliorates various complications to diabetes and prevents age related arterial stiffening and cardiac hypertrophy, effects probably dependent on inhibition of AGEs formation. Secondly, AMG inhibits NO synthase particularly the inducible NO synthase isoform making AMG an important pharmacological tool. The inducible NO... (More)

Aminoguanidine (AMG) was prepared more than 100 years ago. During the last 10 years two important effects of AMG have been discovered which have made this molecule attract a lot of interest. Firstly, AMG inhibits, in vitro and in vivo, formation of highly reactive advanced glycosylation end products (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. AMG ameliorates various complications to diabetes and prevents age related arterial stiffening and cardiac hypertrophy, effects probably dependent on inhibition of AGEs formation. Secondly, AMG inhibits NO synthase particularly the inducible NO synthase isoform making AMG an important pharmacological tool. The inducible NO synthase isoform is associated with production of large quantities of NO synthase in response to e. g. cytokines. When these effects of AMG were disclosed it had already been known for many years that AMG, in nM concentrations, inhibits diamine oxidase. This enzyme catalyzes degradation of biologically active diamines such as histamine and putrescine. Data obtained from studies using AMG should be interpreted with precaution since this substance interferes with several important regulatory systems. In this review these important targets for AMG are addressed.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Adenosylmethionine Decarboxylase, Amine Oxidase (Copper-Containing), Animals, Enzyme Inhibitors, Glycosylation End Products, Advanced, Guanidines, Humans, Nitric Oxide Synthase
in
Inflammation Research
volume
48
issue
10
pages
7 pages
publisher
Birkhaüser
external identifiers
  • Scopus:0032697984
ISSN
1023-3830
DOI
10.1007/s000110050495
language
English
LU publication?
yes
id
1f490d92-bafa-440a-8af4-c4475ef28fb5
date added to LUP
2016-06-17 16:31:21
date last changed
2016-12-04 04:52:17
@misc{1f490d92-bafa-440a-8af4-c4475ef28fb5,
  abstract     = {<p>Aminoguanidine (AMG) was prepared more than 100 years ago. During the last 10 years two important effects of AMG have been discovered which have made this molecule attract a lot of interest. Firstly, AMG inhibits, in vitro and in vivo, formation of highly reactive advanced glycosylation end products (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. AMG ameliorates various complications to diabetes and prevents age related arterial stiffening and cardiac hypertrophy, effects probably dependent on inhibition of AGEs formation. Secondly, AMG inhibits NO synthase particularly the inducible NO synthase isoform making AMG an important pharmacological tool. The inducible NO synthase isoform is associated with production of large quantities of NO synthase in response to e. g. cytokines. When these effects of AMG were disclosed it had already been known for many years that AMG, in nM concentrations, inhibits diamine oxidase. This enzyme catalyzes degradation of biologically active diamines such as histamine and putrescine. Data obtained from studies using AMG should be interpreted with precaution since this substance interferes with several important regulatory systems. In this review these important targets for AMG are addressed.</p>},
  author       = {Nilsson, B O},
  issn         = {1023-3830},
  keyword      = {Adenosylmethionine Decarboxylase,Amine Oxidase (Copper-Containing),Animals,Enzyme Inhibitors,Glycosylation End Products, Advanced,Guanidines,Humans,Nitric Oxide Synthase},
  language     = {eng},
  number       = {10},
  pages        = {15--509},
  publisher    = {ARRAY(0x92d6cd0)},
  series       = {Inflammation Research},
  title        = {Biological effects of aminoguanidine : an update},
  url          = {http://dx.doi.org/10.1007/s000110050495},
  volume       = {48},
  year         = {1999},
}