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Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis

Saxne, Tore LU and Heinegård, Dick LU (1995) In Journal of Rheumatology 22 (suppl 43). p.71-74
Abstract
Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretical and experimental rationale for such an approach is supported by the results in clinical studies. These studies indicate that simultaneous analysis of multiple cartilage and bone markers in the same SF or serum sample could be useful for defining degree of tissue involvement in rheumatoid arthritis and, possibly, in osteoarthritis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis, Rheumatoid/metabolism, Biomarkers/analysis, Cartilage, Articular/metabolism, Osteoarthritis/metabolism
in
Journal of Rheumatology
volume
22 (suppl 43)
pages
71 - 74
publisher
J Rheumatol Publ Co
external identifiers
  • Scopus:0028917932
ISSN
0315-162X
language
English
LU publication?
yes
id
1f4adcac-f8fd-4864-ade4-14f7842b86ed
date added to LUP
2016-05-07 10:20:16
date last changed
2016-10-13 05:08:16
@misc{1f4adcac-f8fd-4864-ade4-14f7842b86ed,
  abstract     = {Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretical and experimental rationale for such an approach is supported by the results in clinical studies. These studies indicate that simultaneous analysis of multiple cartilage and bone markers in the same SF or serum sample could be useful for defining degree of tissue involvement in rheumatoid arthritis and, possibly, in osteoarthritis.},
  author       = {Saxne, Tore and Heinegård, Dick},
  issn         = {0315-162X},
  keyword      = {Arthritis, Rheumatoid/metabolism,Biomarkers/analysis,Cartilage, Articular/metabolism,Osteoarthritis/metabolism},
  language     = {eng},
  pages        = {71--74},
  publisher    = {ARRAY(0x8ed1f68)},
  series       = {Journal of Rheumatology},
  title        = {Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis},
  volume       = {22 (suppl 43)},
  year         = {1995},
}