Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis
(1995) In Journal of Rheumatology 22 (suppl 43). p.71-74- Abstract
- Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretical and experimental rationale for such an approach is supported by the results in clinical studies. These studies indicate that simultaneous analysis of multiple cartilage and bone markers in the same SF or serum sample could be useful for defining degree of tissue involvement in rheumatoid arthritis and, possibly, in osteoarthritis.
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https://lup.lub.lu.se/record/1f4adcac-f8fd-4864-ade4-14f7842b86ed
- author
- Saxne, Tore LU and Heinegård, Dick LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arthritis, Rheumatoid/metabolism, Biomarkers/analysis, Cartilage, Articular/metabolism, Osteoarthritis/metabolism
- in
- Journal of Rheumatology
- volume
- 22 (suppl 43)
- pages
- 71 - 74
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- scopus:0028917932
- ISSN
- 0315-162X
- language
- English
- LU publication?
- yes
- id
- 1f4adcac-f8fd-4864-ade4-14f7842b86ed
- date added to LUP
- 2016-05-07 10:20:16
- date last changed
- 2021-01-03 03:57:03
@article{1f4adcac-f8fd-4864-ade4-14f7842b86ed, abstract = {{Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretical and experimental rationale for such an approach is supported by the results in clinical studies. These studies indicate that simultaneous analysis of multiple cartilage and bone markers in the same SF or serum sample could be useful for defining degree of tissue involvement in rheumatoid arthritis and, possibly, in osteoarthritis.}}, author = {{Saxne, Tore and Heinegård, Dick}}, issn = {{0315-162X}}, keywords = {{Arthritis, Rheumatoid/metabolism; Biomarkers/analysis; Cartilage, Articular/metabolism; Osteoarthritis/metabolism}}, language = {{eng}}, pages = {{71--74}}, publisher = {{Journal of Rheumatology Publishing Company Limited}}, series = {{Journal of Rheumatology}}, title = {{Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis}}, volume = {{22 (suppl 43)}}, year = {{1995}}, }