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Serum analyses of tissue derived macromolecules and markers of inflammation in early rheumatoid arthritis. Relation to development of joint destructions in hands and feet

Fex, E; Eberhardt, Kerstin LU and Saxne, Tore LU (1997) In British Journal of Rheumatology 36. p.1161-1165
Abstract
SUMMARY
We have previously shown that serum concentrations of cartilage oligomeric matrix protein (COMP) are increased early in
rheumatoid arthritis (RA) patients who subsequently develop advanced large-joint destruction. A prognostic value for joint
damage of serum concentrations of hyaluronan (HA) is also suggested by previous studies. In contrast, serum concentrations
of bone sialoprotein (BSP) have not been useful for identifying patients with progressive large-joint destruction. In the present
study, we have examined the hypothesis that serum concentrations of these tissue-derived markers are of prognostic value in
RA for the development of radiographically detectable joint damage in hands and feet. Serum... (More)
SUMMARY
We have previously shown that serum concentrations of cartilage oligomeric matrix protein (COMP) are increased early in
rheumatoid arthritis (RA) patients who subsequently develop advanced large-joint destruction. A prognostic value for joint
damage of serum concentrations of hyaluronan (HA) is also suggested by previous studies. In contrast, serum concentrations
of bone sialoprotein (BSP) have not been useful for identifying patients with progressive large-joint destruction. In the present
study, we have examined the hypothesis that serum concentrations of these tissue-derived markers are of prognostic value in
RA for the development of radiographically detectable joint damage in hands and feet. Serum concentrations of COMP, HA
and BSP were quanti®ed in samples obtained from 62 patients within the ®rst year after onset of RA and were related to the
development of radiographically detectable damage in these joints after 5 yr. Neither the serum concentrations of COMP nor
of BSP at inclusion predicted joint damage in hands and feet after 5 yr, and the concentration of these proteins did not
change over the 5 yr period. However, the serum concentration of HA at inclusion correlated with the radiographic score at
the 5 yr follow-up (r= 0.425, P < 0.01), but was not a better predictor in this respect than the erythrocyte sedimentation
rate or C-reactive protein levels at inclusion. Thus, serum concentrations of the three studied tissue-derived macromolecules
were in this study not useful for identifying patients prone to small-joint destruction. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
RHEUMATOID ARTHRITIS, JOINT DESTRUCTION, feet, hands
in
British Journal of Rheumatology
volume
36
pages
1161 - 1165
external identifiers
  • Scopus:0031408673
language
English
LU publication?
yes
id
1fa48207-a40c-4e62-928c-72084a80b8d2
date added to LUP
2016-05-07 11:00:31
date last changed
2016-05-26 13:22:21
@misc{1fa48207-a40c-4e62-928c-72084a80b8d2,
  abstract     = {SUMMARY<br>
We have previously shown that serum concentrations of cartilage oligomeric matrix protein (COMP) are increased early in<br>
rheumatoid arthritis (RA) patients who subsequently develop advanced large-joint destruction. A prognostic value for joint<br>
damage of serum concentrations of hyaluronan (HA) is also suggested by previous studies. In contrast, serum concentrations<br>
of bone sialoprotein (BSP) have not been useful for identifying patients with progressive large-joint destruction. In the present<br>
study, we have examined the hypothesis that serum concentrations of these tissue-derived markers are of prognostic value in<br>
RA for the development of radiographically detectable joint damage in hands and feet. Serum concentrations of COMP, HA<br>
and BSP were quanti®ed in samples obtained from 62 patients within the ®rst year after onset of RA and were related to the<br>
development of radiographically detectable damage in these joints after 5 yr. Neither the serum concentrations of COMP nor<br>
of BSP at inclusion predicted joint damage in hands and feet after 5 yr, and the concentration of these proteins did not<br>
change over the 5 yr period. However, the serum concentration of HA at inclusion correlated with the radiographic score at<br>
the 5 yr follow-up (r= 0.425, P &lt; 0.01), but was not a better predictor in this respect than the erythrocyte sedimentation<br>
rate or C-reactive protein levels at inclusion. Thus, serum concentrations of the three studied tissue-derived macromolecules<br>
were in this study not useful for identifying patients prone to small-joint destruction.},
  author       = {Fex, E and Eberhardt, Kerstin and Saxne, Tore},
  keyword      = {RHEUMATOID ARTHRITIS,JOINT DESTRUCTION,feet,hands},
  language     = {eng},
  pages        = {1161--1165},
  series       = {British Journal of Rheumatology},
  title        = {Serum analyses of tissue derived macromolecules and markers of inflammation in early rheumatoid arthritis. Relation to development of joint destructions in hands and feet},
  volume       = {36},
  year         = {1997},
}