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Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study.

Englund, Martin LU ; Felson, David T; Guermazi, Ali; Roemer, Frank W; Wang, Ke; Crema, Michel D; Lynch, John A; Sharma, Leena; Segal, Neil A and Lewis, Cora E, et al. (2011) In Annals of the Rheumatic Diseases 70. p.1733-1739
Abstract
OBJECTIVES:



Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee MRI. This study investigates potential risk factors for medial meniscal lesions or extrusion in middle-aged and elderly persons.

METHODS:



Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, USA (the Multicenter Osteoarthritis Study). 644 men and women aged 50-79 years with or at high risk of knee osteoarthritis (Kellgren and Lawrence grade 0-2) but with normal medial meniscal status at baseline were studied. Paired baseline and 30-month 1.0 T knee MRI were scored for meniscal lesions and extrusion (pathology) and the following systemic,... (More)
OBJECTIVES:



Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee MRI. This study investigates potential risk factors for medial meniscal lesions or extrusion in middle-aged and elderly persons.

METHODS:



Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, USA (the Multicenter Osteoarthritis Study). 644 men and women aged 50-79 years with or at high risk of knee osteoarthritis (Kellgren and Lawrence grade 0-2) but with normal medial meniscal status at baseline were studied. Paired baseline and 30-month 1.0 T knee MRI were scored for meniscal lesions and extrusion (pathology) and the following systemic, knee-specific and compartment-specific potential risk factors were evaluated: age, sex, body mass index, bony enlargement of finger joints, knee trauma, leg-length inequality and knee alignment.

RESULTS:



Of 791 knees, 77 (9.7%) had medial meniscal pathology at 30 months follow-up. 61 of the 77 (81%) had no report of trauma during follow-up. Including all potential risk factors in the multivariable model, the adjusted OR for medial meniscal pathology was 4.14 (95% CI 2.06 to 8.31) for knee trauma during follow-up, 1.64 (1.00 to 2.70) for five or more bony enlargements of finger joints (vs ≤4) and 2.00 (1.18 to 3.40) for varus alignment (vs not varus) at baseline examination. Obesity was a risk factor for the development of meniscal extrusion, OR 3.04 (1.04 to 8.93) but not for meniscal lesions, OR 1.15 (0.52 to 2.54).

CONCLUSIONS:



Apart from knee trauma, possible generalised osteoarthritis, expressed as multiple bony enlargements of finger joints, varus alignment and obesity are risk factors for medial meniscal pathology. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
70
pages
1733 - 1739
publisher
British Medical Association
external identifiers
  • WOS:000294491600006
  • PMID:21646417
  • Scopus:80052463045
ISSN
1468-2060
DOI
10.1136/ard.2011.150052
language
English
LU publication?
yes
id
3565eb98-f4a1-45b1-a766-896d7c9b331e (old id 2008414)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21646417?dopt=Abstract
date added to LUP
2011-07-04 11:16:19
date last changed
2016-11-27 04:28:40
@misc{3565eb98-f4a1-45b1-a766-896d7c9b331e,
  abstract     = {OBJECTIVES:<br/><br>
<br/><br>
Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee MRI. This study investigates potential risk factors for medial meniscal lesions or extrusion in middle-aged and elderly persons.<br/><br>
METHODS:<br/><br>
<br/><br>
Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, USA (the Multicenter Osteoarthritis Study). 644 men and women aged 50-79 years with or at high risk of knee osteoarthritis (Kellgren and Lawrence grade 0-2) but with normal medial meniscal status at baseline were studied. Paired baseline and 30-month 1.0 T knee MRI were scored for meniscal lesions and extrusion (pathology) and the following systemic, knee-specific and compartment-specific potential risk factors were evaluated: age, sex, body mass index, bony enlargement of finger joints, knee trauma, leg-length inequality and knee alignment.<br/><br>
RESULTS:<br/><br>
<br/><br>
Of 791 knees, 77 (9.7%) had medial meniscal pathology at 30 months follow-up. 61 of the 77 (81%) had no report of trauma during follow-up. Including all potential risk factors in the multivariable model, the adjusted OR for medial meniscal pathology was 4.14 (95% CI 2.06 to 8.31) for knee trauma during follow-up, 1.64 (1.00 to 2.70) for five or more bony enlargements of finger joints (vs ≤4) and 2.00 (1.18 to 3.40) for varus alignment (vs not varus) at baseline examination. Obesity was a risk factor for the development of meniscal extrusion, OR 3.04 (1.04 to 8.93) but not for meniscal lesions, OR 1.15 (0.52 to 2.54).<br/><br>
CONCLUSIONS:<br/><br>
<br/><br>
Apart from knee trauma, possible generalised osteoarthritis, expressed as multiple bony enlargements of finger joints, varus alignment and obesity are risk factors for medial meniscal pathology.},
  author       = {Englund, Martin and Felson, David T and Guermazi, Ali and Roemer, Frank W and Wang, Ke and Crema, Michel D and Lynch, John A and Sharma, Leena and Segal, Neil A and Lewis, Cora E and Nevitt, Michael C},
  issn         = {1468-2060},
  language     = {eng},
  pages        = {1733--1739},
  publisher    = {ARRAY(0x940d650)},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study.},
  url          = {http://dx.doi.org/10.1136/ard.2011.150052},
  volume       = {70},
  year         = {2011},
}