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Obstetric Outcomes in Women with Turner Karyotype.

Hagman, Arne; Källén, Karin LU ; Barrenäs, M-L; Landin-Wilhelmsen, K; Hanson, C; Bryman, I and Wennerholm, U-B (2011) In The Journal of clinical endocrinology and metabolism 96. p.3475-3482
Abstract
Context: Women with Turner syndrome (TS) have high risk of cardiovascular complications and hypertensive disorders. Few studies have analyzed obstetric outcome in women with TS. Objective: This study compared obstetric outcome in women with TS karyotype with women in the general population. Design: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register between 1973 and 2007. Obstetric outcome in singletons was compared with a reference group of 56,000 women from the general population. Obstetric outcome in twins was described separately. Results: A total of 202 singletons and three sets of twins were born to 115 women with a TS karyotype that was unknown in 52% at time of pregnancy. At first delivery,... (More)
Context: Women with Turner syndrome (TS) have high risk of cardiovascular complications and hypertensive disorders. Few studies have analyzed obstetric outcome in women with TS. Objective: This study compared obstetric outcome in women with TS karyotype with women in the general population. Design: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register between 1973 and 2007. Obstetric outcome in singletons was compared with a reference group of 56,000 women from the general population. Obstetric outcome in twins was described separately. Results: A total of 202 singletons and three sets of twins were born to 115 women with a TS karyotype that was unknown in 52% at time of pregnancy. At first delivery, TS women of singletons were older than controls (median 30 vs. 26 yr, P < 0.0001). Preeclampsia occurred in 6.3 vs. 3.0% (P = 0.07). Aortic dissection occurred in one woman. Compared with the general population, the gestational age was shorter in children born by TS women (-6.4 d, P = 0.0067), and median birth weight was lower (-208 g, P = 0.0012), but sd scores for weight and length at birth were similar. The cesarean section rate was 35.6% in TS women and 11.8% in controls (P < 0.0001). There was no difference in birth defects in children of TS women as compared with controls. Conclusions: Obstetric outcomes in women with a TS karyotype were mostly favorable. Singletons of TS women had shorter gestational age, but similar size at birth, adjusted for gestational age and sex. Birth defects did not differ between TS and controls. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of clinical endocrinology and metabolism
volume
96
pages
3475 - 3482
publisher
The Endocrine Society
external identifiers
  • WOS:000296750600053
  • PMID:21865365
  • Scopus:80655137174
ISSN
1945-7197
DOI
10.1210/jc.2011-1421
language
English
LU publication?
yes
id
0e605c0d-ecdf-46f7-972c-8ea630f27c26 (old id 2150713)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21865365?dopt=Abstract
date added to LUP
2011-09-04 13:14:57
date last changed
2016-11-09 14:39:54
@misc{0e605c0d-ecdf-46f7-972c-8ea630f27c26,
  abstract     = {Context: Women with Turner syndrome (TS) have high risk of cardiovascular complications and hypertensive disorders. Few studies have analyzed obstetric outcome in women with TS. Objective: This study compared obstetric outcome in women with TS karyotype with women in the general population. Design: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register between 1973 and 2007. Obstetric outcome in singletons was compared with a reference group of 56,000 women from the general population. Obstetric outcome in twins was described separately. Results: A total of 202 singletons and three sets of twins were born to 115 women with a TS karyotype that was unknown in 52% at time of pregnancy. At first delivery, TS women of singletons were older than controls (median 30 vs. 26 yr, P &lt; 0.0001). Preeclampsia occurred in 6.3 vs. 3.0% (P = 0.07). Aortic dissection occurred in one woman. Compared with the general population, the gestational age was shorter in children born by TS women (-6.4 d, P = 0.0067), and median birth weight was lower (-208 g, P = 0.0012), but sd scores for weight and length at birth were similar. The cesarean section rate was 35.6% in TS women and 11.8% in controls (P &lt; 0.0001). There was no difference in birth defects in children of TS women as compared with controls. Conclusions: Obstetric outcomes in women with a TS karyotype were mostly favorable. Singletons of TS women had shorter gestational age, but similar size at birth, adjusted for gestational age and sex. Birth defects did not differ between TS and controls.},
  author       = {Hagman, Arne and Källén, Karin and Barrenäs, M-L and Landin-Wilhelmsen, K and Hanson, C and Bryman, I and Wennerholm, U-B},
  issn         = {1945-7197},
  language     = {eng},
  pages        = {3475--3482},
  publisher    = {ARRAY(0x7f406a0)},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Obstetric Outcomes in Women with Turner Karyotype.},
  url          = {http://dx.doi.org/10.1210/jc.2011-1421},
  volume       = {96},
  year         = {2011},
}