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National EQ-5D tariffs and quality-adjusted life-year estimation: comparison of UK, US and Danish utilities in south Swedish rheumatoid arthritis patients.

Karlsson, Johan LU ; Nilsson, Jan-Åke LU ; Neovius, Martin; Kristensen, Lars Erik LU ; Gülfe, Anders LU ; Saxne, Tore LU and Geborek, Pierre LU (2011) In Annals of the Rheumatic Diseases 70. p.2163-2166
Abstract
OBJECTIVE:

To study how the choice of national EQ-5D tariff may affect utility and incremental quality-adjusted life-year (QALY) estimates.



METHODS:

South Swedish rheumatoid arthritis patients in an observational study, starting and continuing anti-tumour necrosis factor (TNF) monotherapy (n=54) or anti-TNF plus methotrexate (n=215) for 1 year during May 2002 to April 2009, were included. EQ-5D questionnaires were completed at baseline, 3, 6 and 12 months. Utilities and accumulated QALY were compared using the UK, US and Danish EQ-5D tariffs. Utilities for all 243 possible EQ-5D health states were also compared.



RESULTS:

US utilities were generally higher than UK, with Danish... (More)
OBJECTIVE:

To study how the choice of national EQ-5D tariff may affect utility and incremental quality-adjusted life-year (QALY) estimates.



METHODS:

South Swedish rheumatoid arthritis patients in an observational study, starting and continuing anti-tumour necrosis factor (TNF) monotherapy (n=54) or anti-TNF plus methotrexate (n=215) for 1 year during May 2002 to April 2009, were included. EQ-5D questionnaires were completed at baseline, 3, 6 and 12 months. Utilities and accumulated QALY were compared using the UK, US and Danish EQ-5D tariffs. Utilities for all 243 possible EQ-5D health states were also compared.



RESULTS:

US utilities were generally higher than UK, with Danish falling in between. A substantial 1-year mean utility improvement was seen in both study groups using all tariffs (UK 0.28 vs 0.29; US 0.18 vs 0.19; Danish 0.20 vs 0.22). Adjusting for baseline differences between groups, the incremental QALY gain of combined treatment was 0.09 using the UK tariff, while 0.06 according to both US and Danish tariffs. Inter-tariff disagreement in utility and accumulated QALY varied irregularly across the range of utilities.



CONCLUSIONS:

Applying different national EQ-5D tariffs to the same data may result in substantially different incremental QALY estimates, crucial knowledge when interpreting cost-utility analyses. Studies using different tariffs cannot be directly compared. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
70
pages
2163 - 2166
publisher
British Medical Association
external identifiers
  • WOS:000297571900020
  • PMID:21859684
  • Scopus:84860395765
ISSN
1468-2060
DOI
10.1136/ard.2011.153437
language
English
LU publication?
yes
id
5a8f33a9-a336-4d1b-8911-47a43f7b21c8 (old id 2150779)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21859684?dopt=Abstract
date added to LUP
2011-09-04 13:31:02
date last changed
2016-11-20 04:22:12
@misc{5a8f33a9-a336-4d1b-8911-47a43f7b21c8,
  abstract     = {OBJECTIVE:<br/><br>
To study how the choice of national EQ-5D tariff may affect utility and incremental quality-adjusted life-year (QALY) estimates.<br/><br>
<br/><br>
METHODS:<br/><br>
South Swedish rheumatoid arthritis patients in an observational study, starting and continuing anti-tumour necrosis factor (TNF) monotherapy (n=54) or anti-TNF plus methotrexate (n=215) for 1 year during May 2002 to April 2009, were included. EQ-5D questionnaires were completed at baseline, 3, 6 and 12 months. Utilities and accumulated QALY were compared using the UK, US and Danish EQ-5D tariffs. Utilities for all 243 possible EQ-5D health states were also compared.<br/><br>
<br/><br>
RESULTS:<br/><br>
US utilities were generally higher than UK, with Danish falling in between. A substantial 1-year mean utility improvement was seen in both study groups using all tariffs (UK 0.28 vs 0.29; US 0.18 vs 0.19; Danish 0.20 vs 0.22). Adjusting for baseline differences between groups, the incremental QALY gain of combined treatment was 0.09 using the UK tariff, while 0.06 according to both US and Danish tariffs. Inter-tariff disagreement in utility and accumulated QALY varied irregularly across the range of utilities.<br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
Applying different national EQ-5D tariffs to the same data may result in substantially different incremental QALY estimates, crucial knowledge when interpreting cost-utility analyses. Studies using different tariffs cannot be directly compared.},
  author       = {Karlsson, Johan and Nilsson, Jan-Åke and Neovius, Martin and Kristensen, Lars Erik and Gülfe, Anders and Saxne, Tore and Geborek, Pierre},
  issn         = {1468-2060},
  language     = {eng},
  pages        = {2163--2166},
  publisher    = {ARRAY(0xb48e190)},
  series       = {Annals of the Rheumatic Diseases},
  title        = {National EQ-5D tariffs and quality-adjusted life-year estimation: comparison of UK, US and Danish utilities in south Swedish rheumatoid arthritis patients.},
  url          = {http://dx.doi.org/10.1136/ard.2011.153437},
  volume       = {70},
  year         = {2011},
}