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Determinants for malignancy in surgically treated adrenal lesions.

Wright, Lucie ; Nordenström, Erik LU and Almquist, Martin LU (2012) In Langenbeck's Archives of Surgery 397. p.217-223
Abstract
PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had... (More)
PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance. CONCLUSIONS: Size of adrenal lesion, suspicious radiological findings and history of malignancy were factors associated with malignancy. (Less)
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type
Contribution to journal
publication status
published
subject
in
Langenbeck's Archives of Surgery
volume
397
pages
217 - 223
publisher
Springer
external identifiers
  • wos:000300493600008
  • pmid:21935703
  • scopus:84858861954
  • pmid:21935703
ISSN
1435-2451
DOI
10.1007/s00423-011-0849-9
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Surgery (Lund) (013009000)
id
f8cb93bb-c374-4712-8fa8-a421aaaa6869 (old id 2168705)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21935703?dopt=Abstract
date added to LUP
2016-04-04 09:03:53
date last changed
2022-05-16 22:39:21
@article{f8cb93bb-c374-4712-8fa8-a421aaaa6869,
  abstract     = {{PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance. CONCLUSIONS: Size of adrenal lesion, suspicious radiological findings and history of malignancy were factors associated with malignancy.}},
  author       = {{Wright, Lucie and Nordenström, Erik and Almquist, Martin}},
  issn         = {{1435-2451}},
  language     = {{eng}},
  pages        = {{217--223}},
  publisher    = {{Springer}},
  series       = {{Langenbeck's Archives of Surgery}},
  title        = {{Determinants for malignancy in surgically treated adrenal lesions.}},
  url          = {{http://dx.doi.org/10.1007/s00423-011-0849-9}},
  doi          = {{10.1007/s00423-011-0849-9}},
  volume       = {{397}},
  year         = {{2012}},
}