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LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1

Osada, H; Grutz, G G; Axelson, H LU ; Forster, A and Rabbitts, T H (1997) In Leukemia 11 (Suppl 3). p.12-307
Abstract

The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.

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organization
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Contribution to journal
publication status
published
subject
keywords
Adaptor Proteins, Signal Transducing, Animals, Basic Helix-Loop-Helix Transcription Factors, COS Cells, DNA-Binding Proteins, Erythroid-Specific DNA-Binding Factors, Erythropoiesis, GATA1 Transcription Factor, Helix-Loop-Helix Motifs, Humans, LIM Domain Proteins, Leukemia, Erythroblastic, Acute, Leukemia, T-Cell, Metalloproteins, Proto-Oncogene Proteins, Recombinant Proteins, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Zinc Fingers
in
Leukemia
volume
11
issue
Suppl 3
pages
6 pages
publisher
Nature Publishing Group
external identifiers
  • Scopus:0030824801
ISSN
0887-6924
language
English
LU publication?
yes
id
21f613e4-c250-4888-9935-95b13080bcc9
date added to LUP
2016-08-09 09:13:27
date last changed
2016-10-13 05:12:04
@misc{21f613e4-c250-4888-9935-95b13080bcc9,
  abstract     = {<p>The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.</p>},
  author       = {Osada, H and Grutz, G G and Axelson, H and Forster, A and Rabbitts, T H},
  issn         = {0887-6924},
  keyword      = {Adaptor Proteins, Signal Transducing,Animals,Basic Helix-Loop-Helix Transcription Factors,COS Cells,DNA-Binding Proteins,Erythroid-Specific DNA-Binding Factors,Erythropoiesis,GATA1 Transcription Factor,Helix-Loop-Helix Motifs,Humans,LIM Domain Proteins,Leukemia, Erythroblastic, Acute,Leukemia, T-Cell,Metalloproteins,Proto-Oncogene Proteins,Recombinant Proteins,Transcription Factors,Transcription, Genetic,Transfection,Tumor Cells, Cultured,Zinc Fingers},
  language     = {eng},
  number       = {Suppl 3},
  pages        = {12--307},
  publisher    = {ARRAY(0x8566018)},
  series       = {Leukemia},
  title        = {LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1},
  volume       = {11 },
  year         = {1997},
}