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Polysaccharide-K (PSK) in Cancer - Old Story, New Possibilities?

Sun, Chen LU ; Rosendahl, Ann LU ; Wang, Xiangdong LU ; Wu, D Q and Andersson, Roland LU (2012) In Current Medicinal Chemistry 19(5). p.757-762
Abstract
Polysaccharide-K (PSK, Krestin) is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia, especially in Japan. PSK has a documented anti-tumor activity both in vitro and in vitro, in various types of cancers, including colorectal, gastric, breast, liver, pancreatic, and lung cancer. Despite PSK having been studied for about 40 years as an immune modulator and biological response modifier, the mechanisms of action by PSK have not yet been clearly and completely elucidated. This review aims to provide an up-to-date account for the effects of PSK in cancer with the hope of thereby providing an increased understanding of the molecular mechanisms of PSK and also its potential as... (More)
Polysaccharide-K (PSK, Krestin) is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia, especially in Japan. PSK has a documented anti-tumor activity both in vitro and in vitro, in various types of cancers, including colorectal, gastric, breast, liver, pancreatic, and lung cancer. Despite PSK having been studied for about 40 years as an immune modulator and biological response modifier, the mechanisms of action by PSK have not yet been clearly and completely elucidated. This review aims to provide an up-to-date account for the effects of PSK in cancer with the hope of thereby providing an increased understanding of the molecular mechanisms of PSK and also its potential as an additive in modern cancer therapy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Medicinal Chemistry
volume
19
issue
5
pages
757 - 762
publisher
Bentham Science Publishers
external identifiers
  • WOS:000300443700011
  • PMID:22204346
  • Scopus:84863284114
ISSN
0929-8673
language
English
LU publication?
yes
id
9bdec14f-03a4-4fc4-88d6-6b77ac6ee9b6 (old id 2273493)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22204346?dopt=Abstract
date added to LUP
2012-01-03 16:04:51
date last changed
2016-11-17 13:35:25
@misc{9bdec14f-03a4-4fc4-88d6-6b77ac6ee9b6,
  abstract     = {Polysaccharide-K (PSK, Krestin) is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia, especially in Japan. PSK has a documented anti-tumor activity both in vitro and in vitro, in various types of cancers, including colorectal, gastric, breast, liver, pancreatic, and lung cancer. Despite PSK having been studied for about 40 years as an immune modulator and biological response modifier, the mechanisms of action by PSK have not yet been clearly and completely elucidated. This review aims to provide an up-to-date account for the effects of PSK in cancer with the hope of thereby providing an increased understanding of the molecular mechanisms of PSK and also its potential as an additive in modern cancer therapy.},
  author       = {Sun, Chen and Rosendahl, Ann and Wang, Xiangdong and Wu, D Q and Andersson, Roland},
  issn         = {0929-8673},
  language     = {eng},
  number       = {5},
  pages        = {757--762},
  publisher    = {ARRAY(0x940e290)},
  series       = {Current Medicinal Chemistry},
  title        = {Polysaccharide-K (PSK) in Cancer - Old Story, New Possibilities?},
  volume       = {19},
  year         = {2012},
}