Bone regeneration during distraction osteogenesis: mechano-regulation by shear strain and fluid velocity
Isaksson, Hanna LU
; Comas, Olivier
; Mediavilla, Jesus
; Wilson, Wouter
; Huiskes, Rik
and Ito, Keita
(2007)
In Journal of Biomechanics
40(9).
p.2002-2011
- Abstract
- Corroboration of mechano-regulation algorithms is difficult, partly because repeatable experimental outcomes under a controlled mechanical environment are necessary, but rarely available. In distraction osteogenesis (DO), a controlled displacement is used to regenerate large volumes of new bone, with predictable and reproducible outcomes, allowing to computationally study the potential mechanisms that stimulate bone formation. We hypothesized that mechano-regulation by octahedral shear strain and fluid velocity can predict the spatial and temporal tissue distributions seen during experimental DO. Variations in predicted tissue distributions due to alterations in distraction rate and frequency could then also be studied. An in vivo ovine... (More)
- Corroboration of mechano-regulation algorithms is difficult, partly because repeatable experimental outcomes under a controlled mechanical environment are necessary, but rarely available. In distraction osteogenesis (DO), a controlled displacement is used to regenerate large volumes of new bone, with predictable and reproducible outcomes, allowing to computationally study the potential mechanisms that stimulate bone formation. We hypothesized that mechano-regulation by octahedral shear strain and fluid velocity can predict the spatial and temporal tissue distributions seen during experimental DO. Variations in predicted tissue distributions due to alterations in distraction rate and frequency could then also be studied. An in vivo ovine tibia experiment evaluating bone-segment transport (distraction, 1 mm/day) over an intramedullary nail was used for comparison. A 2D axisymmetric finite element model, with a geometry originating from the experimental data, was created and included into a previously developed model of tissue differentiation. Cells migrated and proliferated into the callus, differentiating into fibroblasts, chondrocytes or osteoblasts, dependent on the biophysical stimuli. Matrix production was modelled with an osmotic swelling model to allow tissues to grow at individual rates. The temporal and spatial tissue distributions predicted by the computational model agreed well with those seen experimentally. In addition, it was observed that decreased distraction rate (0.5 mm/d vs. 0.25 mm/d) increased the overall time needed for complete bone regeneration, whereas increased distraction frequency (0.5 mm/12 h vs. 0.25 mm/6 h) stimulated faster bone regeneration, as found in experimental findings by others. Thus, the algorithm regulated by octahedral shear strain and fluid velocity was able to predict the bone regeneration patterns dependent on distraction rate and frequency during DO. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2275359
- author
- Isaksson, Hanna
LU
; Comas, Olivier
; Mediavilla, Jesus
; Wilson, Wouter
; Huiskes, Rik
and Ito, Keita
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biomechanics
- volume
- 40
- issue
- 9
- pages
- 2002 - 2011
- publisher
- Elsevier
- external identifiers
-
- scopus:34249720606
- ISSN
- 1873-2380
- language
- English
- LU publication?
- no
- id
- 78f40ada-fdc5-4122-b657-25d95525b9fa (old id 2275359)
- date added to LUP
- 2016-04-04 14:31:10
- date last changed
- 2023-09-11 14:51:38
@article{78f40ada-fdc5-4122-b657-25d95525b9fa,
abstract = {{Corroboration of mechano-regulation algorithms is difficult, partly because repeatable experimental outcomes under a controlled mechanical environment are necessary, but rarely available. In distraction osteogenesis (DO), a controlled displacement is used to regenerate large volumes of new bone, with predictable and reproducible outcomes, allowing to computationally study the potential mechanisms that stimulate bone formation. We hypothesized that mechano-regulation by octahedral shear strain and fluid velocity can predict the spatial and temporal tissue distributions seen during experimental DO. Variations in predicted tissue distributions due to alterations in distraction rate and frequency could then also be studied. An in vivo ovine tibia experiment evaluating bone-segment transport (distraction, 1 mm/day) over an intramedullary nail was used for comparison. A 2D axisymmetric finite element model, with a geometry originating from the experimental data, was created and included into a previously developed model of tissue differentiation. Cells migrated and proliferated into the callus, differentiating into fibroblasts, chondrocytes or osteoblasts, dependent on the biophysical stimuli. Matrix production was modelled with an osmotic swelling model to allow tissues to grow at individual rates. The temporal and spatial tissue distributions predicted by the computational model agreed well with those seen experimentally. In addition, it was observed that decreased distraction rate (0.5 mm/d vs. 0.25 mm/d) increased the overall time needed for complete bone regeneration, whereas increased distraction frequency (0.5 mm/12 h vs. 0.25 mm/6 h) stimulated faster bone regeneration, as found in experimental findings by others. Thus, the algorithm regulated by octahedral shear strain and fluid velocity was able to predict the bone regeneration patterns dependent on distraction rate and frequency during DO.}},
author = {{Isaksson, Hanna and Comas, Olivier and Mediavilla, Jesus and Wilson, Wouter and Huiskes, Rik and Ito, Keita}},
issn = {{1873-2380}},
language = {{eng}},
number = {{9}},
pages = {{2002--2011}},
publisher = {{Elsevier}},
series = {{Journal of Biomechanics}},
title = {{Bone regeneration during distraction osteogenesis: mechano-regulation by shear strain and fluid velocity}},
volume = {{40}},
year = {{2007}},
}