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Normative childhood repetitive routines and obsessive compulsive symptomatology in 6-year-old twins

Bolton, Derek; Rijsdijk, Fruhling; Eley, Thalia; O'Connor, Thomas; Briskman, Jacqueline and Perrin, Sean LU (2009) In Journal of Child Psychology and Psychiatry 50(9). p.1139-1146
Abstract
Background: To investigate the association between normative repetitive routines of childhood and

paediatric obsessive compulsive symptom syndrome (OCSS) and the extent to which it is genetically

mediated. Methods: In a two-phase design a community sample of 4,662 6-year-old twin-pairs were

sampled and 854 pairs were assessed in the second phase for normative repetitive routines using the

Childhood Routines Inventory (CRI) and for OCSS by maternal-informant diagnostic interview. The

OCSS phenotype was defined using standard diagnostic criteria for obsessive compulsive disorder, though regardless of impairment. Results: In the bivariate model, correlation between the CRI defined phenotype and the... (More)
Background: To investigate the association between normative repetitive routines of childhood and

paediatric obsessive compulsive symptom syndrome (OCSS) and the extent to which it is genetically

mediated. Methods: In a two-phase design a community sample of 4,662 6-year-old twin-pairs were

sampled and 854 pairs were assessed in the second phase for normative repetitive routines using the

Childhood Routines Inventory (CRI) and for OCSS by maternal-informant diagnostic interview. The

OCSS phenotype was defined using standard diagnostic criteria for obsessive compulsive disorder, though regardless of impairment. Results: In the bivariate model, correlation between the CRI defined phenotype and the OCSS phenotype was estimated to be .40 (95% CI .27–.50), and this correlation was attributable wholly to additive genetic effects. The bivariate model also provided estimates of heritability of the two phenotypes separately: 55% (95% CI 80–89%) for the OCSS phenotype, with the remaining variance attributable mainly to non-shared environment, and 50% (95% CI 39–62%) for CRI assessed normative repetitive routines of childhood, with 36% of the remaining variance attributable to shared environment and 14% to non-shared. Conclusions: The moderate correlation between normative childhood repetitive routines and obsessive compulsive symptomatology, attributable to genetic factors, is consistent with the hypothesis that high levels of this trait in young children constitute a risk factor for the development of obsessive compulsive symptoms. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Obsessive compulsive disorder, Childhood Routines Inventory, children, twins, genetics.
in
Journal of Child Psychology and Psychiatry
volume
50
issue
9
pages
1139 - 1146
publisher
Wiley-Blackwell
external identifiers
  • Scopus:69249150844
DOI
10.1111/j.1469-7610.2009.02094.x
language
English
LU publication?
no
id
e1096139-e257-4d3b-96aa-f39fbb8b0243 (old id 2373288)
alternative location
http://www.wiley.com/bw/journal.asp?ref=0021-9630
date added to LUP
2012-03-26 11:13:13
date last changed
2016-10-13 04:43:14
@misc{e1096139-e257-4d3b-96aa-f39fbb8b0243,
  abstract     = {Background: To investigate the association between normative repetitive routines of childhood and<br/><br>
paediatric obsessive compulsive symptom syndrome (OCSS) and the extent to which it is genetically<br/><br>
mediated. Methods: In a two-phase design a community sample of 4,662 6-year-old twin-pairs were<br/><br>
sampled and 854 pairs were assessed in the second phase for normative repetitive routines using the<br/><br>
Childhood Routines Inventory (CRI) and for OCSS by maternal-informant diagnostic interview. The<br/><br>
OCSS phenotype was defined using standard diagnostic criteria for obsessive compulsive disorder, though regardless of impairment. Results: In the bivariate model, correlation between the CRI defined phenotype and the OCSS phenotype was estimated to be .40 (95% CI .27–.50), and this correlation was attributable wholly to additive genetic effects. The bivariate model also provided estimates of heritability of the two phenotypes separately: 55% (95% CI 80–89%) for the OCSS phenotype, with the remaining variance attributable mainly to non-shared environment, and 50% (95% CI 39–62%) for CRI assessed normative repetitive routines of childhood, with 36% of the remaining variance attributable to shared environment and 14% to non-shared. Conclusions: The moderate correlation between normative childhood repetitive routines and obsessive compulsive symptomatology, attributable to genetic factors, is consistent with the hypothesis that high levels of this trait in young children constitute a risk factor for the development of obsessive compulsive symptoms.},
  author       = {Bolton, Derek and Rijsdijk, Fruhling and Eley, Thalia and O'Connor, Thomas and Briskman, Jacqueline and Perrin, Sean},
  keyword      = {Obsessive compulsive disorder,Childhood Routines Inventory,children,twins,genetics.},
  language     = {eng},
  number       = {9},
  pages        = {1139--1146},
  publisher    = {ARRAY(0x7a7b390)},
  series       = {Journal of Child Psychology and Psychiatry},
  title        = {Normative childhood repetitive routines and obsessive compulsive symptomatology in 6-year-old twins},
  url          = {http://dx.doi.org/10.1111/j.1469-7610.2009.02094.x},
  volume       = {50},
  year         = {2009},
}