Duration and morbidity of chronic immune thrombocytopenic purpura in children: Five-year follow-up of a Nordic cohort.
(2012) In Acta paediatrica 101(7). p.761-766- Abstract
- Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP).
Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L.
Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall... (More) - Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP).
Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L.
Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall admission rate was 0.4 per year of thrombocytopenia, decreasing during follow-up as thrombocytopenia converted to milder degrees. Early recovery within 2 years of diagnosis occurred in 35%, was associated with low morbidity, and was more likely in young children with abrupt onset of symptoms.
Conclusion: In a Nordic cohort of children with chronic ITP one half had recovered 5 years after diagnosis, more than half never required hospitalization, and less than 10% experienced serious bleeding episodes, always with a platelet count <20 x 10(9) /L. Aggressive management can be restricted to the minority of children with continuing severe thrombocytopenia and frequent, clinically significant bleeding events. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2431633
- author
- Rosthøj, Steen ; Rajantie, Jukka ; Treutiger, Iris ; Zeller, Bernward ; Tedgård, Ulf LU and Henter, Jan-Inge
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta paediatrica
- volume
- 101
- issue
- 7
- pages
- 761 - 766
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000304715200029
- pmid:22429281
- pmid:22429281
- scopus:85027919805
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2012.02671.x
- language
- English
- LU publication?
- no
- id
- 0c86b106-b57f-45d7-8eb4-be9e91e54459 (old id 2431633)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22429281?dopt=Abstract
- date added to LUP
- 2016-04-04 09:15:14
- date last changed
- 2022-03-23 04:43:05
@article{0c86b106-b57f-45d7-8eb4-be9e91e54459,
abstract = {{Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP). <br/><br>
<br/><br>
Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L. <br/><br>
<br/><br>
Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall admission rate was 0.4 per year of thrombocytopenia, decreasing during follow-up as thrombocytopenia converted to milder degrees. Early recovery within 2 years of diagnosis occurred in 35%, was associated with low morbidity, and was more likely in young children with abrupt onset of symptoms. <br/><br>
<br/><br>
Conclusion: In a Nordic cohort of children with chronic ITP one half had recovered 5 years after diagnosis, more than half never required hospitalization, and less than 10% experienced serious bleeding episodes, always with a platelet count <20 x 10(9) /L. Aggressive management can be restricted to the minority of children with continuing severe thrombocytopenia and frequent, clinically significant bleeding events. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.}},
author = {{Rosthøj, Steen and Rajantie, Jukka and Treutiger, Iris and Zeller, Bernward and Tedgård, Ulf and Henter, Jan-Inge}},
issn = {{1651-2227}},
language = {{eng}},
number = {{7}},
pages = {{761--766}},
publisher = {{Wiley-Blackwell}},
series = {{Acta paediatrica}},
title = {{Duration and morbidity of chronic immune thrombocytopenic purpura in children: Five-year follow-up of a Nordic cohort.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2012.02671.x}},
doi = {{10.1111/j.1651-2227.2012.02671.x}},
volume = {{101}},
year = {{2012}},
}