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Laparoscopic extended pelvic lymphadenectomy for staging can be performed with limited morbidity and short hospital stay in patients with prostate cancer.

Liedberg, Fredrik LU ; Kjölhede, Henrik and Sundqvist, Pernilla (2012) In Scandinavian journal of urology and nephrology 46(5). p.332-336
Abstract
Objective:

Assessing lymph-node status in prostate cancer patients with high accuracy is only possible with surgical staging, despite the evolution of modern imaging techniques. The use of surgical staging has to be balanced against the complications of the procedure, the individual patient's risk for harbouring metastasesand the consequences for the treatment of the patient if such metastases are present. The aim of this study was to investigate complications at 90 days using a standardized method (Clavien) in a consecutive series of patients submitted to laparoscopic extendedpelvic lymphadenectomy.



Material and methods:

This population-based study included 133 high-risk prostate cancer patients... (More)
Objective:

Assessing lymph-node status in prostate cancer patients with high accuracy is only possible with surgical staging, despite the evolution of modern imaging techniques. The use of surgical staging has to be balanced against the complications of the procedure, the individual patient's risk for harbouring metastasesand the consequences for the treatment of the patient if such metastases are present. The aim of this study was to investigate complications at 90 days using a standardized method (Clavien) in a consecutive series of patients submitted to laparoscopic extendedpelvic lymphadenectomy.



Material and methods:

This population-based study included 133 high-risk prostate cancer patients scheduled for external beam radiation. Laparoscopic extended pelvic lymphadenectomy and registration of complications wereperformed in a standardized fashion. Complications were registered on a five-grade scale, and differences between groups were compared with the chi-squared test.



Results:

The mean hospital stay was 1.3 days. Only three patients (2%) suffered from grade 3 complications after surgery, whereas 35 patients (26%) had grade 1 complications and another 11 patients (8%) were treated for grade 2 complications. Of all patients, 35% had lymph-node metastasis, of whom 50% received intensified oncological treatment including adjuvant androgen deprivation and regional lymph-node radiation. Thus, 65% of the patients could be spared regional lymph-node radiation and its associated long-term toxicity.



Conclusions:

Laparoscopic extended pelvic lymphadenectomy can be performed with minimal significant complications and short hospital stay in patients with high-risk prostate cancer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian journal of urology and nephrology
volume
46
issue
5
pages
332 - 336
publisher
Taylor & Francis
external identifiers
  • WOS:000308951000003
  • PMID:22564040
  • Scopus:84866525645
ISSN
1651-2065
DOI
10.3109/00365599.2012.681062
language
English
LU publication?
yes
id
5a8ae590-09a2-42b1-9ca4-e9cd336d7900 (old id 2609046)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22564040?dopt=Abstract
date added to LUP
2012-06-03 13:10:46
date last changed
2016-11-18 11:24:00
@misc{5a8ae590-09a2-42b1-9ca4-e9cd336d7900,
  abstract     = {Objective:<br/><br>
Assessing lymph-node status in prostate cancer patients with high accuracy is only possible with surgical staging, despite the evolution of modern imaging techniques. The use of surgical staging has to be balanced against the complications of the procedure, the individual patient's risk for harbouring metastasesand the consequences for the treatment of the patient if such metastases are present. The aim of this study was to investigate complications at 90 days using a standardized method (Clavien) in a consecutive series of patients submitted to laparoscopic extendedpelvic lymphadenectomy. <br/><br>
<br/><br>
Material and methods:<br/><br>
 This population-based study included 133 high-risk prostate cancer patients scheduled for external beam radiation. Laparoscopic extended pelvic lymphadenectomy and registration of complications wereperformed in a standardized fashion. Complications were registered on a five-grade scale, and differences between groups were compared with the chi-squared test. <br/><br>
<br/><br>
Results:<br/><br>
The mean hospital stay was 1.3 days. Only three patients (2%) suffered from grade 3 complications after surgery, whereas 35 patients (26%) had grade 1 complications and another 11 patients (8%) were treated for grade 2 complications. Of all patients, 35% had lymph-node metastasis, of whom 50% received intensified oncological treatment including adjuvant androgen deprivation and regional lymph-node radiation. Thus, 65% of the patients could be spared regional lymph-node radiation and its associated long-term toxicity. <br/><br>
<br/><br>
Conclusions:<br/><br>
 Laparoscopic extended pelvic lymphadenectomy can be performed with minimal significant complications and short hospital stay in patients with high-risk prostate cancer.},
  author       = {Liedberg, Fredrik and Kjölhede, Henrik and Sundqvist, Pernilla},
  issn         = {1651-2065},
  language     = {eng},
  number       = {5},
  pages        = {332--336},
  publisher    = {ARRAY(0xa952b30)},
  series       = {Scandinavian journal of urology and nephrology},
  title        = {Laparoscopic extended pelvic lymphadenectomy for staging can be performed with limited morbidity and short hospital stay in patients with prostate cancer.},
  url          = {http://dx.doi.org/10.3109/00365599.2012.681062},
  volume       = {46},
  year         = {2012},
}