Advanced

Multiplex sibling history of coronary heart disease is a strong risk factor for coronary heart disease.

Zöller, Bengt LU ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2012) In European Heart Journal 33(22). p.2849-2855
Abstract
Aims:

Familial risks for coronary heart disease (CHD) in families with multiple affected siblings have not been thoroughly studied. This nationwide cohort study aimed to determine familial risks for hospitalization or death due to CHD in families with multiple affected siblings.



Methods and results:

The study is a nationwide follow-up study. The Swedish Multigeneration Register data on 0-76-year-old subjects were linked to Hospital Discharge Register and Cause of Death Register data for 1964-2008. Standardized incidence ratios (SIRs) were calculated for individuals whose siblings were hospitalized or died (without previous hospitalization, i.e. primary fatal cases) due to CHD compared with those whose... (More)
Aims:

Familial risks for coronary heart disease (CHD) in families with multiple affected siblings have not been thoroughly studied. This nationwide cohort study aimed to determine familial risks for hospitalization or death due to CHD in families with multiple affected siblings.



Methods and results:

The study is a nationwide follow-up study. The Swedish Multigeneration Register data on 0-76-year-old subjects were linked to Hospital Discharge Register and Cause of Death Register data for 1964-2008. Standardized incidence ratios (SIRs) were calculated for individuals whose siblings were hospitalized or died (without previous hospitalization, i.e. primary fatal cases) due to CHD compared with those whose siblings were not affected. The procedure was repeated for spouses. Among a total of 185 810 cases of hospitalization or death due to CHD, the SIRs for hospitalization and death in the siblings of affected probands were 1.82 (95% CI: 1.27-2.60) and 1.60 (95% CI: 1.10-2.36), respectively. The SIRs for hospitalization in siblings of two and three affected probands were 6.92 (95% CI: 4.77-10.03) and 7.88 (95% CI: 5.31-11.70), respectively. The SIRs for death in siblings of two and three affected probands were 7.31 (95% CI: 4.76-11.19) and 6.61 (95% CI: 3.91-11.10), respectively. Spouses had low overall familial risks (SIR = 1.05, 95% CI: 1.05-1.06).



Conclusion:

Family history of multiple affected siblings increases the CHD risk. Family history is not a binary trait. There are degrees of risk associated with family history with more than one affected sibling. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Heart Journal
volume
33
issue
22
pages
2849 - 2855
publisher
Oxford University Press
external identifiers
  • WOS:000311303700017
  • PMID:22719024
  • Scopus:84869425848
ISSN
1522-9645
DOI
10.1093/eurheartj/ehs161
language
English
LU publication?
yes
id
38d16c3f-5631-4d05-b1c1-a4a310b95485 (old id 2859196)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22719024?dopt=Abstract
date added to LUP
2012-07-04 18:37:29
date last changed
2016-11-27 04:28:54
@misc{38d16c3f-5631-4d05-b1c1-a4a310b95485,
  abstract     = {Aims:<br/><br>
Familial risks for coronary heart disease (CHD) in families with multiple affected siblings have not been thoroughly studied. This nationwide cohort study aimed to determine familial risks for hospitalization or death due to CHD in families with multiple affected siblings.<br/><br>
<br/><br>
Methods and results:<br/><br>
The study is a nationwide follow-up study. The Swedish Multigeneration Register data on 0-76-year-old subjects were linked to Hospital Discharge Register and Cause of Death Register data for 1964-2008. Standardized incidence ratios (SIRs) were calculated for individuals whose siblings were hospitalized or died (without previous hospitalization, i.e. primary fatal cases) due to CHD compared with those whose siblings were not affected. The procedure was repeated for spouses. Among a total of 185 810 cases of hospitalization or death due to CHD, the SIRs for hospitalization and death in the siblings of affected probands were 1.82 (95% CI: 1.27-2.60) and 1.60 (95% CI: 1.10-2.36), respectively. The SIRs for hospitalization in siblings of two and three affected probands were 6.92 (95% CI: 4.77-10.03) and 7.88 (95% CI: 5.31-11.70), respectively. The SIRs for death in siblings of two and three affected probands were 7.31 (95% CI: 4.76-11.19) and 6.61 (95% CI: 3.91-11.10), respectively. Spouses had low overall familial risks (SIR = 1.05, 95% CI: 1.05-1.06).<br/><br>
<br/><br>
Conclusion:<br/><br>
Family history of multiple affected siblings increases the CHD risk. Family history is not a binary trait. There are degrees of risk associated with family history with more than one affected sibling.},
  author       = {Zöller, Bengt and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1522-9645},
  language     = {eng},
  number       = {22},
  pages        = {2849--2855},
  publisher    = {ARRAY(0xc70b718)},
  series       = {European Heart Journal},
  title        = {Multiplex sibling history of coronary heart disease is a strong risk factor for coronary heart disease.},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehs161},
  volume       = {33},
  year         = {2012},
}